ABSTRACT
Lhermitte-Duclos disease (LDD), also known as dysplastic gangliocytoma, is a rare cerebellar lesion. It has long been regarded as avascular. We report two patients with surgically proven LDD in whom contrast enhancement was observed on MRI. Neuropathological examination revealed proliferation of veins. We suggest that peripheral enhancement of LDD probably reflects vascular proliferation of the cerebellar venous draining system, and should be considered part of the imaging features of LDD.
Subject(s)
Cerebellar Neoplasms/diagnosis , Contrast Media , Ganglioneuroma/diagnosis , Radiographic Image Enhancement , Adult , Cerebellar Neoplasms/pathology , Ganglioneuroma/pathology , Humans , Magnetic Resonance Imaging , Male , Tomography, X-Ray ComputedABSTRACT
We assessed the prevalence of menstrual migraine and its restrictions on daily activities in a representative Dutch population sample of 1181 Dutch women, aged 13-55 years. Further, we evaluated the potential role of oral contraceptives, and how menstrual migraine is treated. More than half suffered from menstrual complaints, a substantial proportion reported headache or migraine as a frequent problem. Use of oral contraceptives seemed to reduce the occurrence of menstrual complaints, but not the occurrence of headache and migraine. In our study, the prevalence of menstrual migraine (3%) is lower than in the literature, most probably because we did not use a selected group of patients but a population-based sample of ordinary women. It was confirmed that attacks of menstrual migraine are more severe, of longer duration, and more resistant to treatment than migraine attacks at other times of the month.
Subject(s)
Menstruation Disturbances/epidemiology , Migraine Disorders/epidemiology , Activities of Daily Living , Adolescent , Adult , Analgesics/therapeutic use , Child , Contraceptives, Oral , Female , Humans , Menstruation Disturbances/complications , Menstruation Disturbances/drug therapy , Migraine Disorders/etiology , Netherlands/epidemiology , PrevalenceABSTRACT
OBJECTIVE: To evaluate topiramate as monotherapy in adults and children with recently diagnosed, localization-related epilepsy, comparing two dosages of topiramate in a multicenter, randomized, double-blind study. METHODS: Adults and children (>/=3 years of age) were eligible if the maximum interval since epilepsy diagnosis was 3 years and patients had one to six partial-onset seizures during a 3-month retrospective baseline. At study entry, patients (N = 252) were untreated or receiving one antiepileptic drug for less than 1 month. After randomization to 50 or 500 mg/d topiramate (25 or 200 mg/d if weight
