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Chem Commun (Camb)
; 58(37): 5582-5585, 2022 May 05.
Article
in English
| MEDLINE
| ID: mdl-35393986
ABSTRACT
Crystalline salts of the low solubility and low permeability drug naftopidil were investigated with mono-, di-, tri-, and tetrafluorobenzoic acids as coformers to show that 245TFBA (2,4,5-trifluorobenzoic acid) is the optimal salt with faster dissolution and high permeability, thereby opening the study of fluorinated coformers in pharmaceutical cocrystals and salts.