ABSTRACT
From January 1st 1970 to December 31 1987, 178 consecutive cervical cancer Ib patients were treated at the Istituto del Radio, University of Brescia, by means of radiotherapy alone. In spite of the negative selection of the patients (advanced age, poor general conditions, associated pathologies) the results were good: 5-year cumulative survival was 86.5%, with a total failure rate of 13.5% (24 failures: 18 in the pelvis, 3 metastases and 3 both). The incidence of major complications (G2-G3-G4 of the Italian-French glossary) was 20% (36 patients): 19 G2, 15 G3 and 2 G4. The results in terms of survival and complications were related to the prognostic factors of the tumor (histology, grading, tumor size), of the patient (age, Karnofsky scale, associated pathologies, number of erythrocytes and hemoglobin rate) and treatment modalities (total dose, fractionation, combination of intracavitary brachytherapy and external beam).
Subject(s)
Uterine Cervical Neoplasms/radiotherapy , Adult , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Middle Aged , Neoplasm Staging , Radiotherapy/adverse effects , Survival Rate , Uterine Cervical Neoplasms/mortality , Uterine Cervical Neoplasms/pathologyABSTRACT
The post-surgical malignant recurrences of bronchogenic cancer may be classified as local, regional, locoregional. The present series is based on 115 patients observed in 1982-1987. In all of them a tumour recurrence was clinically and/or radiologically suspected: the histological findings or the follow-up confirmed such a diagnosis in 52 cases. A correct radiological assessment is based on a full knowledge of three items: 1) early and late complications of the surgical intervention; 2) available diagnostic tools for a differential diagnosis between usual post-operatory sequelae and neoplastic recurrences. 3) pathologic history of the patient and his tumour.
Subject(s)
Carcinoma, Bronchogenic/surgery , Lung Neoplasms/surgery , Neoplasm Recurrence, Local/diagnostic imaging , Carcinoma, Bronchogenic/diagnostic imaging , Follow-Up Studies , Humans , Lung Neoplasms/diagnostic imaging , Pneumonectomy , Tomography, X-Ray ComputedABSTRACT
From 1974 through 1982, 286 patients with histologically proven bladder cancer (Tis 8, T1 62, T2 109, T3 86, T4 21 NXMO) were treated with external irradiation after transurethral resection. Irradiation was given with 260 degrees arc technique photon beam from a Cobalt Unit; the tumor doses ranged from 52.5 to 65 Gy in 21-50 days, with a TDF between 75 and 110. The analysis was conducted with the log rank test on the cumulative percent survival (CPS) at 5 years. The study pointed out the importance of risk factors other than clinical stage on cumulative survival in bladder cancer. Prognostic factors associated with a relatively successful outcome (p less than 0.001) were the Karnofsky performance status (100 vs others) (CPS 75% vs 30%), the absence of ureteral obstruction on the initial intravenous pyelogram (CPS 50% vs 35%), a negative urine culture (CPS 60% vs 30%), normal bladder capacity (CPS 50% vs 35%), low-grade histology (CPS 65% vs 35%), and grossly complete resection (55% vs 40%). The data from this analysis should be taken into consideration when radical radiotherapy is considered in new clinical trials.
