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Antivir Ther ; 9(5): 811-7, 2004 Oct.
Article in English | MEDLINE | ID: mdl-15535419

ABSTRACT

We examined the impact of a lamivudine-containing highly active antiretroviral therapy (HAART) regimen on 164 hepatitis B virus/HIV co-infected individuals starting their first HAART. Lamivudine-treated patients (accounting for 73% of the study population) showed a significantly lower level of alanine aminotransferase over follow-up [-81.1 mU/ml mean difference; 95% confidence intervals (95% CI): -30.3; -131.7, P=0.003] and a significantly reduced risk of liver-related morbidity/mortality [Relative hazard (RH)=0.07; 95% CI: 0.01-0.38, P=0.002] than those starting a lamivudine sparing-regimen.


Subject(s)
Antiretroviral Therapy, Highly Active , HIV Infections/complications , Hepatitis B/complications , Hepatitis B/drug therapy , Lamivudine/therapeutic use , Adult , Alanine Transaminase/metabolism , Anti-HIV Agents/administration & dosage , Anti-HIV Agents/therapeutic use , Aspartate Aminotransferases/metabolism , HIV Infections/drug therapy , HIV Infections/virology , HIV-1/drug effects , Hepatitis B/virology , Hepatitis B virus/drug effects , Humans , Lamivudine/administration & dosage , Liver/enzymology , Male , Prospective Studies , Reverse Transcriptase Inhibitors/administration & dosage , Reverse Transcriptase Inhibitors/therapeutic use , Treatment Outcome
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