ABSTRACT
The influence of 5,7-dihydroxytryptamine (5,7-DHT) and 5,6-dihydroxytryptamine (5,6-DHT) on the level of noradrenaline (NA), dopamine (DA), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) in discrete brain areas of mice was studied. Moreover, the level of free and total acetylcholine (Ach) in the whole brain was measured. The behaviour of animals was also observed. 5,7-DHT caused a relatively specific short-term decrease of 5-HT and 5-HIAA level in discrete areas of mice brain with the decrease of DA level in the striatum. This substance seems to produce a relatively specific disruption of central 5-HT neurons in mice. 5,7-DHT is an unspecific neurotoxic drug for mouse brain. Both substances did not affect the gross behaviour of mice.
Subject(s)
5,6-Dihydroxytryptamine/pharmacology , 5,7-Dihydroxytryptamine/pharmacology , Brain/metabolism , Dihydroxytryptamines/pharmacology , Dopamine/metabolism , Hydroxyindoleacetic Acid/metabolism , Norepinephrine/metabolism , Serotonin/metabolism , Acetylcholine/metabolism , Animals , Behavior, Animal/drug effects , Brain/drug effects , Male , MiceABSTRACT
5-hydroxydopamine, unspecific centrally acting false neurotransmitter. Acta Physiol. Pol., 1977, 28 (1): 13-22. 3,4,5-trihydroxyphenetylamine-5-hydroxydopamine (5-OHDA) injected intracerebro-ventricularly decreases the level of noradrenaline, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in different parts of the rat brain. It does not affect acetylcholine level. 5-OHDA causes dose-dependent hypothermia, transient hypertension and depression of locomotor and exploratory activity in rats. This behavioral phenomena are reversed by central chemical sympathectomy elicited by 6-hydroxydopamine. It is concluded that 5-OHDA is an unspecific centrally acting false transmitter.
Subject(s)
Behavior, Animal/drug effects , Brain/drug effects , Hydroxydopamines/pharmacology , Animals , Dose-Response Relationship, Drug , Exploratory Behavior/drug effects , Hypertension/chemically induced , Hypothermia/chemically induced , Male , Motor Activity/drug effects , Norepinephrine/antagonists & inhibitors , Rats , Serotonin AntagonistsABSTRACT
In male Wistar rats PGF2alpha or PGE1 were injected intracerebroventricularly (icv) in a dose of 1 or 10 mug. Immediately or 1 hr after injection the locomotor and exploratory activity were measured. The levels of noradrenaline (NA), dopamine (DA) 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and acetylcholine (Ach) were measured in discrete brain areas. Both PGs applied ivc caused the depression of locomotor and exploratory activity in rats. PGE1 acted longer. Both substances but PGE1 more intensively affected the level of estimated biogenic amines in different brain structures. It is concluded that PGF2alpha and E1 are central nervous depressants. Both PGs affect neurons producing NA or 5-HT or Ach in discrete areas of brain in different manner. There is different susceptibility of brain structures on PGs action.