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Bioorg Med Chem
; 22(23): 6665-6671, 2014 Dec 01.
Article
in English
| MEDLINE
| ID: mdl-25458500
ABSTRACT
The synthesis of 9-(ß-d-1,3-dioxolan-4-yl)2,6-diaminopurine nucleoside phosphoramidate prodrugs as well as various 2-amino-6-carbamoylpurine dioxolane derivatives and their phosphoramidates prodrugs is reported. Their ability to block HIV and HBV replication along with their cytotoxicity toward HepG2, human lymphocyte, CEM and Vero cells was also assessed.