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1.
Biochemistry (Mosc) ; 83(4): 350-358, 2018 Apr.
Article in English | MEDLINE | ID: mdl-29626922

ABSTRACT

Chromosomes are intricately folded and packaged in the cell nucleus and interact with the nuclear envelope. This complex nuclear architecture has a profound effect on how the genome works and how the cells function. The main goal of review is to highlight recent studies on the effect of chromosome-nuclear envelope interactions on chromatin folding and function in the nucleus. The data obtained suggest that chromosome-nuclear envelope attachments are important for the organization of nuclear architecture in various organisms. A combination of experimental cell biology methods with computational modeling offers a unique opportunity to explore the fundamental relationships between different aspects of 3D genome organization in greater details. This powerful interdisciplinary approach could reveal how the organization and function of the genome in the nuclear space is affected by the chromosome-nuclear envelope attachments and will enable the development of novel approaches to regulate gene expression.


Subject(s)
Chromosomes/metabolism , Genome, Human , Nuclear Envelope/metabolism , Chromosomes/genetics , Gene Expression Regulation , Genome, Human/genetics , Humans , Nuclear Envelope/genetics
2.
Tsitologiia ; 58(4): 315-9, 2016.
Article in English, Russian | MEDLINE | ID: mdl-30191701

ABSTRACT

Malaria mosquitoes are vectors of dangerous human diseases and a model system for investigations of chromosome evolution, heterochromatin organization, and nuclei architecture in the cells of the reproductive system. Investigations of nurse cells chromosomes are aimed at understanding of mechanisms that cause interspecies differences in the nuclear spatial organization in these cells. One of the most important tasks of this research is the undestanding of molecular organization of the chromosome regions that are attached to the nuclear envelope. In the present review, the recent achievements in this field of research are described and unsolved problems of the spatial chromosome organization are identified.


Subject(s)
Anopheles , Chromosomes, Insect , Ovary/metabolism , Animals , Anopheles/genetics , Anopheles/metabolism , Chromosomes, Insect/genetics , Chromosomes, Insect/metabolism , Female , Species Specificity
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