ABSTRACT
The prevalence of subclinical hypothyroidism (SH) is large and according to various studies is from 3 to 21%. In the Russian Federation to date, there are no major epidemiological studies assessing the functional state of the thyroid gland. It seems relevant to study the TSH level in patients who turned to the clinical units of a large hospital in the North-West region to determine the prevalence of thyroid dysfunction in patients of different sex and age. 5,303 patients were examined, who applied to the I.P. Pavlov SPbSMU clinics for 2017. In all patients the level of TSH and free T4 was determined. SH was considered to increase the level of TSH more than 4.0 mIU/l at a normal level of free T4. Patients were divided into groups by age and TSH level in accordance with existing recommendations. Among the examined patients were 29.26% of men and 70.73% of women. The mean age was 55.08 ± 17.07 years. The TSH level had an abnormal distribution and averaged 2.77 mIU/l (TSH median 1.73 mIU/l). In women the level of TSH was significantly higher in all studied groups of patients (p = 0.0001). Among women, significant differences in the level of TSH between the elderly and young patients (p = 0.015) were found. The incidence of SH in the total group of patients was 10.1%. In the men surveyed, the incidence of SH was 7.3%, and in the female group - 11.3%. In the elderly patients, the incidence of subclinical hypothyroidism in women was 2 times higher than that of men. In most cases (77.4%) in patients with SH, the TSH level was in the range of 4.0-6.9 mIU / L. The clinical significance of minimal thyroid insufficiency requires further study.
Subject(s)
Hypothyroidism/diagnosis , Thyrotropin/blood , Adult , Aged , Female , Humans , Male , Middle Aged , Reference Values , Russia , Thyroid Function TestsABSTRACT
The paper provides a comparative evaluation of the protective effects of combined spinal epidural anesthesia with artificial ventilation (AV) (n=86) versus combined general anesthesia with AV (n=53) from the surgical stress response at abdominal surgery. The surgical stress was estimated by the activities of the sympathoadrenal system, the hypothalamo-pituitary-adrenocortical system, the serum complement system, and lipid peroxidation, and by the blood level of glucose. The findings suggest that the combined spinal epidural anesthesia with AV has a more valid protective activity against poor surgery-associated neurohumoral, hemodynamic, and immunological changes.
Subject(s)
Anesthesia, Epidural/methods , Anesthesia, Spinal/methods , Gastrointestinal Diseases/surgery , Stress, Psychological/prevention & control , Abdomen/surgery , Adult , Aged , Blood Glucose/analysis , Female , Humans , Hydrocortisone/blood , Hypothalamo-Hypophyseal System/metabolism , Lipid Peroxidation , Male , Malondialdehyde/blood , Middle Aged , Monitoring, Physiologic , Pituitary-Adrenal System/metabolism , Respiration, Artificial , Stress, Psychological/diagnosis , Stress, Psychological/metabolismABSTRACT
Nine patients with moderate and severe aspirin bronchial asthma (ABA) received epifamine (a course dose 400 mg) in addition to continuous antiasthmatic therapy. Matched 12 ABA patients received placebo. Epifamine was found to improve the patients' clinical condition, response of distal bronchi to berotek; to promote achievement of long remission and increased production of melatonin. Thus, epifamine is effective and can be used in pathogenetic strategic therapy of ABA.
Subject(s)
Anti-Asthmatic Agents/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Aspirin/adverse effects , Asthma/chemically induced , Asthma/drug therapy , Tissue Extracts/therapeutic use , Adult , Epiphyses , Female , Humans , Male , Middle AgedABSTRACT
Treatment effects reached in 94 patients with bronchial asthma demonstrate that neurogenic, humoral and bioenergetic responses to acupuncture proceed according to adaptation laws and result in reduction of bronchial hyperreactivity. Eosinophilic inflammation in the bronchi diminishes acupuncture efficacy.
Subject(s)
Acupuncture Therapy , Asthma/therapy , Asthma/physiopathology , Bronchial Hyperreactivity/therapy , Combined Modality Therapy , Duodenal Ulcer/therapy , Evaluation Studies as Topic , HumansSubject(s)
Autonomic Nervous System/physiology , Cardiovascular System/innervation , Signal Processing, Computer-Assisted/instrumentation , Adult , Atropine , Autonomic Nervous System/drug effects , Cardiovascular Physiological Phenomena , Female , Heart Function Tests/instrumentation , Heart Function Tests/methods , Humans , Male , Middle Aged , Neostigmine , RussiaSubject(s)
Automation , Autonomic Nervous System/physiology , Blood Circulation/physiology , Respiration/physiology , Adult , Female , Humans , Male , Middle AgedABSTRACT
Changes in the adrenal functional state were revealed during the development of bronchoconstriction induced by allergen inhalation in 7 dogs sensitized with ovalbumin. The decrease in V1 (expiratory flow-volume) on an average by 58% was noted after inhalation of 1000 microG of ovalbumin. The significant decrease in II-hydroxycorticosteroids (II-OCS), adrenaline, noradrenaline, dopamine, and a tendency to the increase in histamine content were observed in the venous blood plasma. The decrease in the adrenaline content in plasma apparently contribute to the development of early bronchoconstrictor response, and the decrease in II-OCS maintain the development and the progress of late bronchoconstrictor response.
