ABSTRACT
In acute experiments on anesthetized rats we showed that L-arginine causes an increase in oxygen-dependent synthetic processes in the liver, particularly associated with mitochondrial polyenzyme systems biosynthesis of bile acids with simultaneous activation in hepatocytes tissue respiration. The level of oxygen tension in the gland is not changed. Implementation of these effects partly involves nitric oxide. In addition, the L-arginine inhibits cholepoiesis without involving to the reaction NO. Dose-dependent influence L-arginine on the bile cholates content may indicate a different effect of this amino acids on metabolic transformation of bile acids such as hydroxylation and conjugation.
Subject(s)
Arginine/pharmacology , Bile Acids and Salts/analysis , Bile/metabolism , Liver/drug effects , Oxygen Consumption/drug effects , Animals , Bile/chemistry , Bile Acids and Salts/biosynthesis , Dose-Response Relationship, Drug , Liver/enzymology , Liver/metabolism , Male , NG-Nitroarginine Methyl Ester/pharmacology , Nitric Oxide/metabolism , Nitric Oxide Synthase/antagonists & inhibitors , RatsABSTRACT
The influence of estron (8 microg/100g of animal's body weight) on the exocrine function of liver and the changes in bile acid composition of bile on different sex rats was studied. It was shown, that hormone at the applied dose, effected choleresis of female rats more effectively. Estron also caused different changes in bile composition. So, estron stimulated bile acid conjugation with taurine and glycin in female rat liver. Increasing of free and conjugated bile acid biosynthesis in male rats was observed.
