US evaluation of patients affected by IBD: how to do it, methods and findings.

Intestinal US has to be performed very accurately, to obtain an exploration of both small bowel and cholical loops that will be the most complete that is possible; so, this technique requires adequately trained operators. Convex and linear probes with frequency between 3.5 and 7.5 MHz are used: the first ones for the panoramic evaluation and to study the middle-distal sigma and rectum; the second ones to perform a detailed examination of the bowel wall. US allows to evaluate not only the thickness and structure of the bowel wall, but also the content and peristalsis of the loops, their compressibility and movability, the perivisceral spaces and the abdominal organs. In Crohn's disease, US, completed everytime by the color-power-Doppler, shows wall thickening until 20 mm and above, with multi-stratified structure that could be regular, or more and more altered until the hypoechogenic view; the bowel vascularisation could be absent or less or more increased, due to the stadium of the disease itself. Furthermore, US allows to demonstrate the presence of stenosis and various other complications (abscesses inside or outside the walls, fistulas, involvement of other organs, free fluid collections); the use of II generation US contrast media could afford information about the activity of the disease. US has a very important role in the follow-up of patients with diagnosis of Crohn's disease, to monitor the response to the medical therapy and to discover complications; US must be performed as first in subjects with abdominal pain and diarrhea, to select the ones that need more invasive examinations.

[The usefulness of computer tomography in planning cochlear implant surgery]. / Utilità della Tomografia Computerizzata nella pianificazione dell'intervento di impianto cocleare.

In recent years, technical progress has created new complex acoustic implants which send an electrical stimulus to the eighth cranial nerve through one or more electrodes inserted through the round window into the scala tympani of the cochlea. The abnormal--mostly osteosclerotic--processes which cause deep hearing loss may prevent electrode insertion. Therefore, internal ear anatomy must be detailed, which is essential to assess the feasibility of surgery and, if surgery is indicated, to plan it properly. High resolution CT (HRCT) was performed on 79 patients to study cochlear patency, round window shape and patency, degree of temporal bone pneumatization and the proximity of vascular structures (carotid artery and jugular vein). On the basis of HRCT results, 14 of 79 patients were excluded from surgery. Comparing HRCT with surgical findings, the authors conclude that HRCT is the method of choice to examine the candidates to cochlear implant thanks to its high spatial resolution and excellent depiction of even the smallest structures. Its only limitation is that it fails to assess the lack of patency of the cochlear canal due to fibrosis, which is not associated with demonstrable density changes (3 of 19 surgical patients). This problem may be solved by submitting the potential surgical candidates to MRI.

[Therapy of malignant hepatic tumors using percutaneous hot saline injections. Feasibility study and preliminary results]. / Terapia dei tumori epatici maligni mediante iniezione percutanea di soluzione fisiologica bollente. Studio di fattibilità e risultati preliminari.

PURPOSE: To investigate the feasibility and the results of percutaneous hot saline injection therapy (PSIT) of liver tumors. MATERIAL AND METHODS: Eight patients with hepatocellular carcinoma (11 nodules), 1 with cholangiocarcinoma and 1 with a metastasis from colon cancer underwent PSIT. The patients were selected according to variable criteria; thus, each patient was considered apart. A boiling saline solution was injected into the hepatic lesions through a needle like those commonly used for percutaneous ethanol injection (PEI). The results were assessed with US, CT, angiography, the measurement of tumor marker levels, the histopathologic examination of needle biopsy material, resected specimens, explanted liver material and follow-up. RESULTS: PSIT was more easily performed and altogether better accepted than PEI; in particular, pain immediately regressed upon infusion interruption. For this reason and for the atoxicity of the injected liquid, relatively large lesions could be treated with a greater volume per session and fewer sessions than with PEI. Treatment outcome was positive in all patients, except for the cholangiocarcinoma patient who required surgery. The only major complication was moderate peritoneal bleeding in a patient with severe coagulopathy. CONCLUSION: PSIT can be considered a useful tool for the local treatment of hepatic tumors. Its systematic use to treat hepatocellular carcinoma must be proceeded by further comparative studies with PEI.

[The diagnostic reliability of percutaneous biopsy specimens obtained under instrumental guidance using 4 different types of needles]. / Attendibilità diagnostica dei prelievi bioptici percutanei eseguiti con guida strumentale utilizzando quattro diversi tipi di aghi.

To assess if the effectiveness of biopsy sampling, whose usefulness is widely recognized, can be influenced by different cutting mechanisms, we compared four different types of needles (A, B, C, D) in 76 patients, each needle being of the same length (15 cm) and calibre (18 G) but with different tip shapes. Forty biopsy samples were obtained with each type of needle for a total of 160 samples in 76 patients; 61 samples were acquired under CT guidance and 99 under US guidance. The results were subdivided in 6 categories based on biopsy result: PI (diagnosis histotype in malignant lesions), PN (diagnosis of malignancy in neoplastic lesions), P (correct diagnosis in benign lesions), S (suspicion of neoplastic lesion), E (misdiagnosis), NI (insufficient material). The results, respectively, for each needle type are: 32.5%, 30%, 2.5%, 7.5%, 12.5% and 15% with needle A; 35%, 30%, 7.5%, 0%, 15% and 12.5% with needle B; 27.5%, 17.5%, 10%, 7.5%, 22.5% and 15% with needle C; 30%, 15%, 7.5%, 15%, 17.5% and 15% with needle D. The sensitivity and specificity for each needle type were, respectively, 84.4% and 85.29% for needle A; 86.66% and 88.57% for needle B; 70% and 73.52% for needle C; 77.41% and 79.41% for needle D. No statistically significant difference was found in the effectiveness of the four needles (chi 2); on the contrary, lesions's size can affect sampling quality.

[Pheochromocytoma in childhood. Report of a case of a familial type in an 8-year-old boy]. / Il feocromocitoma nell'infanzia. Segnalazione di un caso a carattere familiare in un bambino di otto anni

A case of right adrenal pheochromocytoma in an 8-yr-old boy and its successful surgical management are described. Clinical and statistical data are given for this form and its symptomatology and aetiopathogenesis are illustrated. Particular stress is laid on the occasionally misunderstood importance of the part played by continuous hypertension. Early diagnosis and surgery are essential to avoid the onset of serious cardiocirclatory complications.