Effect of acute exercise intensity on cognitive inhibition and well-being: Role of lactate and BDNF polymorphism in the dose-response relationship.

Introduction: There is evidence in the literature that acute exercise can modify cognitive function after the effort. However, there is still some controversy concerning the most effective exercise modality to improve cognitive function in acute interventions. Regarding these different exercise modalities, the dose-response relationship between exercise intensity and cognitive response is one of the most challenging questions in exercise and cognition research. Methods: In this study, we tested the impact of moderate-intensity (MICT), high-intensity (HIIT) exercise sessions, or control situation (CTRL) on cognitive inhibition (measured with the Stroop Test). Thirty-six young college students participated in this study, where a within-subject repeated measure design was used. Results: ANOVA 2×3 demonstrated that HIIT improved the acute cognitive response to a higher degree when compared to MICT or CTRL (p < 0.05). The cognitive improvements correlated with lactate release, providing a plausible molecular explanation for the cognitive enhancement (r < -0.2 and p < 0.05 for all the Stroop conditions). Moreover, a positive trend in wellbeing was observed after both exercise protocols (HIIT and MICT) but not in the CTRL situation. Genetic BDNF single nucleotide polymorphism did not influence any interactions (p < 0.05). Discussion: In this sense, our results suggest that exercise intensity could be a key factor in improved cognitive function following exercise in young college students, with no additional impact of BDNF polymorphism. Moreover, our results also provide evidence that exercise could be a useful tool in improving psychological wellbeing.

Different Exercise Types Produce the Same Acute Inhibitory Control Improvements When the Subjective Intensity Is Equal.

Twenty-eight active older people (67.19 ± 4.91 years) who engaged in physical exercise activity twice a week were recruited to participate in a counterbalanced experimental protocol. The participants performed three different exercise sessions on three different days, one based on aerobic activities, one based on strength exercises with elastic bands, and one based on stationary balance games. During all three sessions, they were encouraged to maintain a moderate subjective intensity (5-6 on the RPE10 scale), and their heart rate was recorded. In addition, all of the participants took a digital version of the Stroop test before and after each session. The study aimed to compare the acute cognitive impacts of different types of exercise sessions in older adults. The participants' heart rate differed between the exercise sessions, but they maintained the RPE intensity. There was a significant improvement in inhibitory control (Stroop test) after all sessions, with no differences between exercise sessions. Moreover, some participants agreed to be genotyped to record the single nucleotide polymorphism of BDNF rs6265. There were no differences between Val/Val and Met carriers at the beginning or end of the exercise sessions. The present study showed similar cognitive improvements with different exercise type sessions when the subjective intensity was maintained.

Mediation effects of cognitive, physical, and motivational reserves on cognitive performance in older people.

Introduction: We study from a multidimensional perspective the different factors that help prevent the development of cognitive impairment in old aging. Methods: This study analyzed in 300 elderly subjects the relationship between cognitive reserve (CR), physical reserve (PR) and motivational reserve (MR) with cognitive impairment. This study also takes into consideration different variables (sex, age, educational level, and institutionalization) that might affect the results in the different types of reserves (CR, physical and MR) and cognitive impairment. Results: The results show that people with a higher cognitive reserve, physical reserve and motivational reserve have less cognitive impairment. Discussion: Therefore, it is important to consider measuring the CR as a variable to diagnose neurodegenerative illnesses but it is also essential to consider the physical state and physical activity, as well as the motivational dimension. With the cognitive reserve and sex variables no significant differences were observed. Age had a negative effect on strategic flexibility, but those with higher CR had better cognitive flexibility and the educational.

Regression-Based Normative Data for Independent and Cognitively Active Spanish Older Adults: Free and Cued Selective Reminding Test, Rey-Osterrieth Complex Figure Test and Judgement of Line Orientation.

The aim of this work was to develop normative data for neuropsychological tests for the assessment of independent and cognitively active Spanish older adults over 55 years of age. METHODS: regression-based normative data were calculated from a sample of 103 nondepressed independent community-dwelling adults aged 55 or older (66% women). The raw data for the Free and Cued Selective Reminding Test (FCSRT), the Rey-Osterrieth Complex Figure Test (ROCF) and the Judgement of Line Orientation Test (JLO) were regressed on age, sex and education. The model predicting the FCSRT delayed-recall (FCSRT-Del) scores also included the FCSRT immediate-recall (FCSRT-Imm) scores. The model predicting the ROCF immediate-recall (ROCF-Imm) scores included the ROCF copy-trial (ROCF-C) scores, and the model predicting the ROCF delayed-recall (ROCF-Del) scores included both the ROCF-C and the ROCF-Imm scores. In order to identify low scores, z-scores were used to determine the discrepancy between the observed and the predicted scores. The base rates of the low scores for both the SABIEX normative data and the published normative data obtained from the general population were compared. RESULTS: the effects of the different sociodemographic variables (age, sex and education) varied throughout the neuropsychological measures. Despite finding similar proportions of low scores between the normative data sets, the agreement was irrelevant or only fair-to-good. CONCLUSIONS: the normative data obtained from the general population might not be sensitive enough to identify low scores in cognitively active older adults, incorrectly classifying them as cognitively normal compared to the less active population.

Regression-Based Normative Data for Independent and Cognitively Active Spanish Older Adults: Digit Span, Letters and Numbers, Trail Making Test and Symbol Digit Modalities Test.

In this work, we developed normative data for the neuropsychological assessment of independent and cognitively active Spanish older adults over 55 years of age. METHOD: Regression-based normative data were calculated from a sample of 103 non-depressed independent community-dwelling adults aged 55 or older (67% women). Raw data for Digit Span (DS), Letters and Numbers (LN), the Trail Making Test (TMT), and the Symbol Digit Modalities Test (SDMT) were regressed on age, sex, and education. The model predicting TMT-B scores also included TMT-A scores. Z-scores for the discrepancy between observed and predicted scores were used to identify low scores. The base rate of low scores for SABIEX normative data was compared to the base rate of low scores using published normative data obtained from the general population. RESULTS: The effects of age, sex, and education varied across neuropsychological measures. Although the proportion of low scores was similar between normative datasets, there was no agreement in the identification of cognitively impaired individuals. CONCLUSIONS: Normative data obtained from the general population might not be sensitive to identify low scores in cognitively active older adults, incorrectly classifying them as cognitively normal compared to the less-active population. We provide a friendly calculator for use in neuropsychological assessment in cognitively active Spanish people aged 55 or older.

Effects of e-Health Training and Social Support Interventions for Informal Caregivers of People with Dementia-A Narrative Review.

Along with the burden commonly experienced by informal caregivers (ICs) of people with dementia (PwD), associated with the progressive decline that accompanies dementia, the lockdown due to the public health crisis has had a great negative impact on the emotional wellbeing, physical health, and social relationships of ICs. Support interventions through telemedicine represent an opportunity for ICs to learn the skills required for the care and maintenance of social networks. In this work, a narrative review of the effects of e-health training and social support interventions was carried out. A literature search was conducted using the ProQuest, Ovid, and Scopus databases. Information regarding social support (SS), psychological interventions, and training for the management of medications and behavioral changes was extracted. One hundred and nine studies were included in this review. Forums and training platforms were the main tools for ICs. The most effective platforms to improve SS include the participation of both ICs and health professionals. However, no significant improvements in objective caring skills were identified. Platforms developed specifically for ICs should be based in tools that ICs are familiar with, because many ICs have not yet incorporated Information and Communication Technologies in many activities of their daily lives. Education in the digitalization to ICs of PwD should be one of the priority objectives in telehealth interventions.

Physical Activity and Life Satisfaction: An Empirical Study in a Population of Senior Citizens.

Objective: The specialised literature indicates that the two key aspects in active ageing are performing physical activity and life satisfaction. Regarding physical activity, this not only improves physical aspects of senior citizens, but also has a positive impact on mental well-being and satisfaction with one's own life. The aim is to demonstrate the relationship between these two variables to explain healthy ageing. Method: In a sample of 300 senior citizen subjects, the influence of various sociodemographic variables (age, sex, institutionalisation, and level of education) on the performance of physical activity and life satisfaction, is analysed. The research design is a non-experimental study with two unique cross-sectional and correlational measurement groups. Results: An analysis of the results indicates that people with a higher level of education present differences in physical and motivational reserves. Furthermore, age and institutionalisation have an impact on physical reserves. Analysis using structural equation models allows key relationships between the variables analysed to be predicted, which can guide the implementation of active ageing. Conclusion: Motivational reserves affect healthy cognitive ageing through their positive impact on cognitive and physical reserves.

Validation and Norms for a Recognition Task for the Spanish Version of the Free and Cued Selective Reminding Test.

OBJECTIVE: The aim of the present work was to develop and validate a recognition task to be used with the Spanish version of the 16 items Free and Cued Selective Reminding Test (FCSRT). METHOD: A total of 96 (67.7% women) cognitively healthy, functionally independent community-dwelling participants aged 55 years or older underwent a comprehensive neuropsychological assessment. A recognition task for the FCSRT was developed that included the original 16 items, 16 semantically related items, and eight unrelated foils. Indices of discriminability (d') and response bias (C), as well as 95% confidence intervals for chance-level responding were calculated. RESULTS: On average, our sample was 65.71 years old (SD = 6.68, range: 55-87), had 11.39 years of formal education (SD = 3.37, range: 3-19), and a Mini-Mental State Examination score = 28.42 (SD = 1.49, range: 25-30). Recognition scores did not differ statistically between sexes, nor did they correlate with demographics. Participants scored at ceiling levels (mean number of Hits = 15.52, SD = 0.906, mean number of False Alarms = 0.27, SD = 0.589). All the participants scored above chance levels. CONCLUSIONS: Normative data from a novel recognition task for the Spanish version of the FCSRT are provided for use in clinical and research settings. Including a recognition task in the assessment of memory functioning might help uncover the pattern of memory impairments in older adults, and can help improve the memory profile of people with amnestic Mild Cognitive Impairment. Future research is warranted to validate and expand the recognition task.

Relationship between Cognitive Reserve and Cognitive Impairment in Autonomous and Institutionalized Older Adults.

It is necessary to determine which variables help prevent the presence of decline or deterioration during the aging process as a function of advancing age. This research analyses the relations between cognitive reserve (CR) and cognitive impairment in 300 individuals. It also aims to confirm the influence of different variables (gender, age, level of studies and institutionalization) in CR and in deterioration in a population of older adults. The results indicate that people with higher CR present less deterioration. Regarding the role of the sociodemographic variables in the level of deterioration and CR, there are no differences between men and women, but there are differences in the variables age, level of studies and institutionalization, in such a way that the older age the greater the cognitive deterioration, the higher the level of studies, the more RC and less deterioration and it was found that the non-institutionalized people present less deterioration and greater CR. It is affirmed that two people with similar clinical characteristics may present different levels of pathology, being the CR the explanation of this fact. The results obtained allow us to affirm that the measurement of CR is considered an essential variable for the diagnosis of neurodegenerative diseases.

Datos normativos del test Barcelona revisado-abreviado para personas mayores cognitivamente activas / Normative data of the abbreviated-revised Barcelona test for cognitively active elderly people

INTRODUCCIÓN: La evaluación neuropsicológica es esencial para identificar los cambios cognitivos que ocurren durante el envejecimiento normal y patológico. Sin embargo, es necesario contar con baremos adaptados a las características del funcionamiento cognitivo de la población diana para reducir la posibilidad de falsos diagnósticos de alteración cognitiva. El objetivo de este trabajo es proporcionar baremos normativos basados en una muestra de personas mayores cognitivamente activas que participan en un programa universitario para personas mayores. MATERIALES Y MÉTODOS: Se analizaron datos de 87 participantes (70,9% mujeres) de 66,73 años de edad media, emparejados por edad y nivel educativo, a quienes se aplicó el test de Barcelona revisado-abreviado. Los datos normativos se calcularon mediante regresión lineal controlando la edad, el sexo y los años de escolaridad. Se analizó la utilidad de estos datos normativos en comparación con los baremos disponibles en el manual del test y obtenidos en la población general. RESULTADOS: La variable con mayor peso en la regresión fueron los años de escolaridad, seguida de la edad y el sexo. Los baremos obtenidos en la muestra de personas cognitivamente activas mostraron un número de puntuaciones bajas diferente al de los datos normativos de la población general. El número de puntuaciones bajas difirió en función de los años de escolaridad y del funcionamiento cognitivo general. CONCLUSIONES: Los datos normativos obtenidos con la población mayor cognitivamente activa podrían ayudar a identificar el funcionamiento cognitivo real de personas mayores cognitivamente activas con mayor precisión que utilizando los baremos establecidos con la población general

INTRODUCTION: Neuropsychological assessment is mandatory in order to identify cognitive changes that occur during either normal or pathological aging. However, normative data adapted to the characteristics of the population are needed in order to reduce the probability of false diagnoses of cognitive impairment. The aim of the present work was to compute normative data for cognitively active elderly people attending a University course for the elderly. MATERIALS AND METHODS: An analysis was performed on the data from 87 participants (70.9% women) with a mean age of 66.73 years who undertook the abbreviated- revised Barcelona test (test de Barcelona revisado-abreviado). Normative data were calculated using linear regressions controlling for age, gender, and years of education. Adjusted normative data were compared with normative data available from the test manual and obtained from the general population. RESULTS: Years of education and gender showed the highest weights in the regression model. Normative data for cognitively active older adults showed a different number of low scores compared to normative data from the general population. The number of low scores were related to years of education and general cognitive functioning. CONCLUSIONS: Normative data obtained from cognitively active older people could help identify more accurately the cognitive functioning of cognitively active older people than do normative data obtained from the general population

[Normative data of the abbreviated-revised Barcelona test for cognitively active elderly people]. / Datos normativos del test Barcelona revisado-abreviado para personas mayores cognitivamente activas.

INTRODUCTION: Neuropsychological assessment is mandatory in order to identify cognitive changes that occur during either normal or pathological aging. However, normative data adapted to the characteristics of the population are needed in order to reduce the probability of false diagnoses of cognitive impairment. The aim of the present work was to compute normative data for cognitively active elderly people attending a University course for the elderly. MATERIALS AND METHODS: An analysis was performed on the data from 87 participants (70.9% women) with a mean age of 66.73 years who undertook the abbreviated- revised Barcelona test (test de Barcelona revisado-abreviado). Normative data were calculated using linear regressions controlling for age, gender, and years of education. Adjusted normative data were compared with normative data available from the test manual and obtained from the general population. RESULTS: Years of education and gender showed the highest weights in the regression model. Normative data for cognitively active older adults showed a different number of low scores compared to normative data from the general population. The number of low scores were related to years of education and general cognitive functioning. CONCLUSIONS: Normative data obtained from cognitively active older people could help identify more accurately the cognitive functioning of cognitively active older people than do normative data obtained from the general population.