High-Density Polyethylene Custom Focusing Lenses for High-Resolution Transient Terahertz Biomedical Imaging Sensors.

Transient terahertz time-domain spectroscopy (THz-TDS) imaging has emerged as a novel non-ionizing and noninvasive biomedical imaging modality, designed for the detection and characterization of a variety of tissue malignancies due to their high signal-to-noise ratio and submillimeter resolution. We report our design of a pair of aspheric focusing lenses using a commercially available lens-design software that resulted in about 200 × 200-µm2 focal spot size corresponding to the 1-THz frequency. The lenses are made of high-density polyethylene (HDPE) obtained using a lathe fabrication and are integrated into a THz-TDS system that includes low-temperature GaAs photoconductive antennae as both a THz emitter and detector. The system is used to generate high-resolution, two-dimensional (2D) images of formalin-fixed, paraffin-embedded murine pancreas tissue blocks. The performance of these focusing lenses is compared to the older system based on a pair of short-focal-length, hemispherical polytetrafluoroethylene (TeflonTM) lenses and is characterized using THz-domain measurements, resulting in 2D maps of the tissue refractive index and absorption coefficient as imaging markers. For a quantitative evaluation of the lens effect on the image resolution, we formulated a lateral resolution parameter, R2080, defined as the distance required for a 20-80% transition of the imaging marker from the bare paraffin region to the tissue region in the same image frame. The R2080 parameter clearly demonstrates the advantage of the HDPE lenses over TeflonTM lenses. The lens-design approach presented here can be successfully implemented in other THz-TDS setups with known THz emitter and detector specifications.

Measurement and control of large diameter ionization waves of arbitrary velocity.

Large diameter, flying focus driven ionization waves of arbitrary velocity (IWAV's) were produced by a defocused laser beam in a hydrogen gas jet, and their spatial and temporal electron density characteristics were measured using a novel, spectrally resolved interferometry diagnostic. A simple analytic model predicts the effects of power spectrum non-uniformity on the IWAV trajectory and transverse profile. This model compares well with the measured data and suggests that spectral shaping can be used to customize IWAV behavior and increase controlled propagation of ionization fronts for plasma-photonics applications.

Characterization of single and double fiber-coupled diffusing spheres.

A fiber-optic sensor, consisting of an optical fiber with and without a 1.59-mm-diameter spherical ceramic tip, inserted into a 19-mm-diameter Spectralon sphere has been characterized. This sensor is evaluated as a large-area omnidirectional sensor. An optical transport measurement system that rotates the sphere about two axes has been designed. The system measured the UV transport efficiency at 351 nm of light impinging on the sphere with an f-6 cone angle. When a bare fiber was placed at the center of the target sphere, the detection sensitivity was biased in the forward direction. The peak of the sensitivity of the inverse integrating sphere shifted from front to back as the bare fiber was withdrawn from the sphere and the numerical aperture of the fiber viewed more of the scattering volume. The response function with respect to the angle of incidence of the dual sphere was much more uniform than that obtained with a bare fiber in the center of the sphere.