ABSTRACT
The authors examined 20 subjects with infantile cerebral palsy, 10 of whom had patella alta, in order to evaluate any difference of extensor force of the quadriceps in the various degrees of flexion of the knee as compared with normal subjects. The objective was to reveal and measure any functional differences between the two groups.
Subject(s)
Cerebral Palsy/physiopathology , Muscles/physiopathology , Patella/physiopathology , Thigh/physiopathology , Biomechanical Phenomena , Cerebral Palsy/pathology , Humans , Muscles/pathology , Patella/pathology , Thigh/pathologyABSTRACT
Erythrocyte ALA-D and urinary coproporphyrins were investigated in 29 road gasoline station workers in order to detect a possible abnormal lead absorption. The ALA-D test represents the most sensitive laboratory device to detect both abnormal lead absorption and possible initial lesions due to lead poisoning. Using the above mentioned laboratory tests evidence of abnormal lead absorption was found in five of the examined subjects. Some remarks on prevention of possible lead intoxication are done.
Subject(s)
Environmental Pollutants/analysis , Gasoline/adverse effects , Lead Poisoning/diagnosis , Occupational Diseases/diagnosis , Petroleum/adverse effects , Adult , Coproporphyrins/urine , Humans , Italy , Lead/adverse effects , Lead Poisoning/urine , Occupational Diseases/urineSubject(s)
Lead Poisoning/etiology , Petroleum , Adult , Environmental Exposure , Humans , Italy , Lead Poisoning/diagnosis , Middle AgedSubject(s)
Erythrocytes/enzymology , Hydro-Lyases/blood , Lead Poisoning/diagnosis , Porphyrins/urine , Humans , Levulinic AcidsSubject(s)
Erythrocytes/enzymology , Hydro-Lyases/blood , Lead Poisoning/enzymology , Animals , Humans , Levulinic AcidsSubject(s)
Glutathione/blood , Hydro-Lyases/blood , Lead Poisoning/blood , Animals , Levulinic Acids/metabolism , Male , RabbitsSubject(s)
Erythrocytes/enzymology , Hydro-Lyases/analysis , Lead Poisoning/diagnosis , Adult , Humans , Levulinic Acids/metabolism , Middle AgedABSTRACT
The action of haem, haemoglobin and other haemoproteins on crude and purified delta-aminolaevulate dehydratase of human erythrocyte is described. The results show a feedback inhibition by haem of porphyrin synthesis at the level of erythrocyte delta-aminolaevulate dehydratase. Some kinetic characteristics of this inhibition are described.