Subject(s)
Marketing of Health Services/methods , Oral Health , Women's Health , Women, Working , Female , Humans , Professional Role , Self Concept , Women's Health ServicesABSTRACT
PURPOSE: To describe the development of a new dentin hypersensitivity treatment, Colgate Sensitive Maximum Strength dentifrice, containing 5% potassium nitrate as the anti-hypersensitivity active agent. The objective was to develop a home-use hypersensitivity dentifrice that would be superior to the market leader, improving on what is available, which also contains 5% potassium nitrate as the anti-hypersensitivity active agent. METHODS: In vivo (clinicals, taste evaluation and rat caries), in vitro (potassium flux) and analytical (rheology, dispensed volume, scanning electron microscopy, electron scanning chemical analysis and radioactive dentin abrasion) methods were performed. RESULTS: The objective was accomplished with the development of a new activated silica technology that resulted in enhanced potassium ion activity. In vitro documentation, supported by clinical studies, demonstrated that the resulting formula is more effective than the market leader for relief of hypersensitivity pain. Fast pain relief in less than 2 weeks and long-lasting protection against pain with regular use have also been clinically documented. Furthermore, FDA-required in vivo and in vitro studies indicate that this formula, which contains 0.45% stannous fluoride (1100 ppm fluoride) as the anti-caries active agent, is effective against caries. Good taste, acceptable rheology, acceptable abrasivity, and cosmetic and chemical stability have all been engineered into this unique dentin hypersensitivity treatment. In summary, a highly efficacious consumer friendly treatment for dentin hypersensitivity has been developed.
Subject(s)
Dentifrices/therapeutic use , Dentin Sensitivity/drug therapy , Nitrates/therapeutic use , Potassium Compounds/therapeutic use , Animals , Cariostatic Agents/therapeutic use , Complex Mixtures , Dental Caries/drug therapy , Dentifrices/chemistry , Dentinal Fluid/physiology , Drug Combinations , Female , Fluorides/therapeutic use , Humans , Male , Phosphates/therapeutic use , Rats , Rats, Inbred Strains , Rheology , Silicon Dioxide , Sodium Fluoride/therapeutic use , TasteABSTRACT
The group concluded that the research productivity of a dental school depended to a large extent on the availability of resources, human and economic. Firstly it requires a group of individuals trained and educated to conduct independent research. Secondly, it requires that these individuals had time to spend on research activities. Thirdly, appropriate space and equipment in which to conduct the research were considered prerequisites. Fourthly, they require an ongoing and appropriate budget. Fifthly, it is essential to have an appropriate climate in the school that encourages and rewards research achievement.
