1.
Mech Ageing Dev
; 50(3): 289-98, 1989 Dec.
Article
in English
| MEDLINE
| ID: mdl-2630837
ABSTRACT
Hexobarbital is a drug widely used to study the capacity of the liver to metabolize drugs. The pharmacokinetics of hexobarbital in 3- and 30-month-old male BN/BiRij rats were studied. The half-life of hexobarbital in 30-month-old rats (39.9 +/- 4.1 min) was significantly higher than that of 3-month-old ones (21.3 +/- 3.8 min). The volume of distribution (ml.kg-1 body weight) did not change with age. The intrinsic clearance, expressed as ml.min-1.kg-1 body weight, of hexobarbital in 30-month-old rats (20.2 +/- 6.6) was half that of the 3-month-old ones (39.5 +/- 7.6). Further studies will be performed to investigate the effect of age on the intrinsic clearance of S(+)- and R(-)- hexobarbital.
Subject(s)
Hexobarbital/pharmacokinetics , Age Factors , Animals , Body Weight , Chromatography, High Pressure Liquid , Hexobarbital/blood , Liver/metabolism , Male , Organ Size , Rats , Rats, Inbred BN
2.
Biochem Pharmacol
; 33(22): 3709-11, 1984 Nov 15.
Article
in English
| MEDLINE
| ID: mdl-6508826