ABSTRACT
Flushing is an essential strategy in maintaining patency of a central vascular access device. However, there is no standard practice regarding flushing techniques. Pulsatile flushing has been discussed in the past based on the principles of fluid dynamics. Recently, in vitro studies regarding pulsatile flushing have shed light on the usefulness of this technique. A critique of the current literature regarding pulsatile flushing compared with standard continuous flushing is presented here.
Subject(s)
Catheterization, Central Venous/adverse effects , Catheterization, Central Venous/instrumentation , Therapeutic Irrigation/methods , Humans , Sodium ChlorideABSTRACT
Blinatumomab has shown great potential for patients with chemotherapy-resistant B-cell acute lymphocytic leukemia. Blinatumomab's toxicity profile includes central nervous system toxicities, as well as cytokine release syndrome. Although neurological toxicities associated with blinatumomab are almost always reversible, early detection and intervention of these toxicities is vital to ensure that patients continue their full course of treatment. Guidelines for the preparation and administration of blinatumomab in both inpatient and outpatient settings, as well as a standardized neurological nursing assessment, were developed to ensure safe and effective administration of blinatumomab.
