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1.
Diagn Cytopathol ; 19(3): 190-3, 1998 Sep.
Article in English | MEDLINE | ID: mdl-9740993

ABSTRACT

Only a few cases of retinoblastomas in older children have been reported and the clinical diagnosis may be difficult. In case, fine-needle aspiration from an atypical retinal mass of an 11-yr-old boy was performed. The vitreous fluid was stained with Diff-Quik for an immediate cytological examination and the diagnosis of retinoblastoma was suggested. The rest of the specimen was separated into two parts. One was stained with May-Grünwald-Giemsa and the other was centrifuged, embedded in paraffin, and finally stained with hematoxylin-eosin-safran. The undifferentiated blue cells were associated with abundant necrotic debris and portions of capillaries with perivascular tumor cells around. The cytoplasm of the tumor cells was strongly stained with neuron-specific enolase antibody. The diagnosis of retinoblastoma was confirmed. The specimen of enucleation confirmed the diagnosis. In conclusion, cytological aspiration can categorically diagnose suspected intraocular tumors of older children in whom clinical and noninvasive investigations have failed to establish the diagnosis.


Subject(s)
Retinal Neoplasms/pathology , Retinoblastoma/pathology , Biopsy, Needle , Child , Eye Enucleation , Humans , Immunoenzyme Techniques , Male , Phosphopyruvate Hydratase/metabolism , Retinal Neoplasms/metabolism , Retinal Neoplasms/surgery , Retinoblastoma/metabolism , Retinoblastoma/surgery
2.
Acta Cytol ; 42(3): 725-8, 1998.
Article in English | MEDLINE | ID: mdl-9622695

ABSTRACT

BACKGROUND: Solid papillary carcinoma of the breast was recently described. This tumor display distinctive clinical and morphologic features. It is an intraductal papillary carcinoma frequently associated with mucinous carcinoma and infiltrating ductal carcinoma not otherwise specified. CASE: Fine needle aspiration cytology (FNAC) of a solid papillary carcinoma of the right breast in an 82-year-old female, demonstrated a cellular specimen of discohesive, small, uniform and ovoid tumor cells, with occasional loose cluster. The cytoplasm was abundant and finely granular. The nuclei were round, without marked atypia. The nucleoli were inconspicuous. SCant mucinous material was present. The diagnosis was confirmed histologically and immunohistochemically. CONCLUSION: The cytologic aspects of solid papillary carcinoma of the breast suggest a carcinoma with endocrine differentiation and a weak mucinous component.


Subject(s)
Biopsy, Needle , Breast Neoplasms/pathology , Breast/pathology , Carcinoma, Papillary/pathology , Aged , Aged, 80 and over , Breast Neoplasms/chemistry , Breast Neoplasms/diagnosis , Carcinoma, Papillary/chemistry , Carcinoma, Papillary/diagnosis , Cell Differentiation , Female , Humans , Mucins/analysis , Neoplasm Proteins/analysis , Neoplastic Stem Cells/pathology
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