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pH-induced release from P2VP-PEO block copolymer vesicles.

Borchert, Uwe; Lipprandt, Ute; Bilang, Matthias; Kimpfler, Andrea; Rank, Anja; Peschka-Süss, Regine; Schubert, Rolf; Lindner, Peter; Förster, Stephan.

Langmuir ; 22(13): 5843-7, 2006 Jun 20.

Article in English | MEDLINE | ID: mdl-16768517

ABSTRACT

The pH-induced release of hydrophilic dyes from poly(2-vinylpyridine-b-ethylene oxide) (P2VP-PEO) block copolymer vesicles is investigated. The structure of the vesicles is characterized using small-angle neutron scattering (SANS) and cryo-electron microscopy (cryo-TEM). A decrease of the pH below 5 leads to protonation and dissolution of the poly-2-vinylpyridine blocks which induces rupture and dissolution of the vesicle membrane. Details of the rupture, dissolution, and release process are studied by fluorescence video microscopy, gel electrophoresis, and high-performance ultrafiltration.

Subject(s)

Polyethylene Glycols/chemistry , Polyvinyls/chemistry , Cryoelectron Microscopy , Hydrogen-Ion Concentration , Membranes, Artificial , Microscopy, Fluorescence , Microscopy, Video , Neutron Diffraction

Direct preparation and loading of lipid and polymer vesicles using inkjets.

Hauschild, Stephan; Lipprandt, Ute; Rumplecker, Anja; Borchert, Uwe; Rank, Anja; Schubert, Rolf; Förster, Stephan.

Small ; 1(12): 1177-80, 2005 Dec.

Article in English | MEDLINE | ID: mdl-17193413

Subject(s)

Ink , Lipids/chemistry , Nanotechnology/methods , Polymers/chemistry , Cryoelectron Microscopy , Fluorescein/pharmacology , Lasers , Magnetic Resonance Spectroscopy , Microscopy, Electron, Transmission , Organic Chemicals/chemistry , Polyethylene Glycols/chemistry , Solvents/chemistry , Ultrafiltration

ABSTRACT

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