Tactile Vision, Epistemic Things and Data Visualization.

Hans-Jörg Rheinberger constructed his historical epistemology of epistemic things by analyzing experimental practices in molecular biology during the 1970s and 80s. With genetic sequencing and multi-omics approaches, data has become a new resource in the life sciences, questioning the applicability of his concept of experimental system. By historicizing Rheinberger's epistemology, the paper focuses on its relatedness to Ludwik Fleck's notion of an aviso of resistance and points to a gradual shift in Rheinberger's emphasis, moving from an initial focus on writing and its differentiality to work on materials, preparations, and representations. By anchoring visualization in these material practices, Rheinberger also sheds new light on the changing conditions of experimentation in the life sciences due to big data, where visualization emphasizes patterns and correlations rather than substrates.

Synonyms and Symptoms of COVID-19 and Individual and Official Actions against the Disease-A Brief Online Survey 6 Months into the Pandemic and on the Threshold of the Second Wave in Germany.

To control the ongoing global pandemic due to SARS-CoV-2, we need to influence people's behavior. To do so, we require information on people's knowledge and perception of the disease and their opinions about the importance of containment measures. Therefore, in August 2020, we conducted an anonymous cross-sectional online survey on these topics in 913 participants in Germany. Participants completed a questionnaire on various synonyms and symptoms of corona virus and specified the importance they attributed to individual and regulatory measures. The virus was linked more closely with most synonyms and the discovery in China than with the places of the first larger European outbreaks. General (cold-like) symptoms, such as "cough" and "fever," were more widely known than COVID-19-specific ones, e.g., "loss of taste and smell." The widely promoted individual measures "distancing," "hygiene," and "(facial) mask wearing" were rated as highly important, as were the corresponding official measures, e.g., the "distancing rule" and "mask mandate." However, the "corona warning app" and a "vaccine mandate" were rated as less important. A subgroup analysis showed broad agreement between the subgroups on nearly all issues. In conclusion, the survey provided information about the German population's perception and knowledge of the coronavirus five months into the pandemic; however, participants were younger and more educated than a representative sample. To learn from the beginning and still ongoing pandemic and develop concepts for the future, we need more conclusive studies, especially on the acceptance of further specified lockdowns, the population's willingness to be vaccinated, and the influence of misinformation on public opinion.

Vital brains: On the entanglement of media, minds, and models.

The advent of functional imaging, hailed as a breakthrough for marrying morphological and functional approaches in brain research, invites a reflection upon the interplay between models, instruments, and theories. Brain research and theorizing about the brain are generally mediated by the research technologies employed. Going back into the history of brain research, the chapter explores the epistemic effects of research technologies by focusing on the localization debate in relation to different visualization strategies. In this way, one can differentiate between abstracting and concretizing approaches to brain modeling. These approaches form the basis for introducing the concept of vital abstraction by revisiting Grey Walter's The Living Brain. Walter's adventures in visualizing brain activity and constructing lively toys are described as a form of brain theorizing that is anchored in empirical research but focuses on the brain's vital activity instead of identifying morphological and structural details. The concept of vital abstraction is further explored by applying the concept of epistemic virtues to evaluate current brain models and for coming to terms with the dynamics of brain research.

Soups and Sparks Revisited John Eccles' Path from the War on Electrical Transmission to Mental Sparks.

In the famous debate whether neurons communicate via chemical mediators or electrical signals, Henry Dale and Otto Loewi mounted powerful evidence on the mediation of nervous activity by chemical transmitters, while John Eccles led the campaign for the electrophysiologists. Eventually, Eccles converted to chemical transmission, when he identified excitatory and inhibitory postsynaptic potentials initiated by the release of chemical neurotransmitters in the synaptic cleft. This well-known episode from the history of neurophysiology counts as a rare instance of philosophy of science advancing scientific research, because the philosopher Karl Popper had encouraged Eccles to theorize an experiment proving the falsity of his own interpretation ­ according to Popper's philosophy of science progressing by falsification. The paper shows how Eccles' intellectual mobilization was grounded in a series of geographical moves, technological adaptations and re-arrangements of his group. This massive travel of people, ideas, instruments, and techniques mediated between the contradictory views, long before Popper kindled Eccles to reflect about the conflicting paradigms and the new theorizing did hardly change his experimental practice. Popper's immediate effect was a critical and reflexive distance that enabled Eccles to present his evidence more persuasively, as can be shown from archival sources. The exchanges between Eccles and Popper thus shaped the philosophy of falsification to a powerful strategy for writing science.

Animating Brains.

A recent paper famously accused the rising field of social neuroscience of using faulty statistics under the catchy title 'Voodoo Correlations in Social Neuroscience'. This Special Issue invites us to take this claim as the starting point for a cross-cultural analysis: in which meaningful ways can recent research in the burgeoning field of functional imaging be described as, contrasted with, or simply compared to animistic practices? And what light does such a reading shed on the dynamics and effectiveness of a century of brain research into higher mental functions? Reviewing the heated debate from 2009 around recent trends in neuroimaging as a possible candidate for current instances of 'soul catching', the paper will then compare these forms of primarily image-based brain research with older regimes, revolving around the deciphering of the brain's electrical activity. How has the move from a decoding paradigm to a representational regime affected the conceptualisation of self, psyche, mind and soul (if there still is such an entity)? And in what ways does modern technoscience provide new tools for animating brains?

How we may think: Imaging and writing technologies across the history of the neurosciences.

In the neurosciences, two alternative regimes of visualization can be differentiated: anatomical preparations for morphological images and physiological studies for functional representations. Adapting a distinction proposed by Peter Galison, this duality of visualization regimes is analyzed here as the contrast between an imaging and a writing approach: the imaging approach, focusing on mimetic representations, preserving material and spatial relations, and the writing approach as used in physiological studies, retaining functional relations. After a dominance of morphological images gathering iconic representations of brains and architectural brain theories, the advent of electroencephalography advanced writing approaches with their indexical signs. Addressing the brain allegedly at its mode of operation, electroencephalography was conceived as recording the brain's intrinsic language, extending the writing approach to include symbolic signs. The availability of functional neuroimaging signaled an opportunity to overcome the duality of imaging and writing, but revived initially a phrenological conflation of form and function, suppressing the writing approach in relation to imaging. More sophisticated visualization modes, however, converted this reductionism to the ontological productivity of social neuroscience and recuperated the theorizing from the writing approach. In light of the ongoing instrumental mediations between brains, data and theories, the question of how we may think, once proposed by Vannevar Bush as a prospect of enhanced human-machine interaction, has become the state of affairs in the entanglements of instruments and organic worlds.

[What kind of debate on prioritisation do we need for the benefit of our health system and society?]. / Welche Debatte um Priorisierung in der medizinischen Versorgung brauchen wir?

The debate on prioritisation aims to generate broad consensus on the social distribution of health care goods. There is nothing wrong with this aim but the political debate around it should include a discussion whether prioritisation is the strategy needed to realize this goal. Obviously, prioritisation follows the currently prevalent logic of evaluation as a universal legitimating strategy but, due to its multiple and unforeseeable effects, this does not necessarily imply that prioritisation will deliver on its promises. Hence, the debate cannot be focused on the appropriate strategies of prioritisation as its proponents seem to intend, but must also include the social costs and potentially adversary effects of this strategy of rationalisation. (As supplied by publisher).

Recording the brain at work: the visible, the readable, and the invisible in electroencephalography.

The electroencephalogram (EEG), the graphic recording of the electric activity of the human brain, kindled far-reaching speculations about the imminent deciphering of mind and brain in the 1930s. Regardless of the thousands of neurons in the human cortex, recording from a person at rest produced a surprisingly regular line oscillating at 10 per second that disappeared at the moment of mental activity. With ever more groups specializing in electroencephalography, however, the deciphering of mind and brain did not materialize but moved further away in the information produced. In the various approaches employed in EEG research, such as the analysis of the graphic code, the search for pathognomic patterns or the imaging of cognitive processing, visualization guided research as well as theorizing, its productivity continued to keep the epistemological question open.

Between local cultures and national styles: units of analysis in the history of electroencephalography.

The history of the discovery of the human electroencephalogram (EEG) and the ensuing implementation of electroencephalography is characterized by striking national differences. The first publication on the EEG in 1929 by the German psychiatrist Hans Berger was met with skepticism. Substantial work in this area did not start before the public demonstration of the EEG by the British neurophysiologist Edgar Douglas Adrian in 1934. Soon afterwards, many groups specialized in the new method, particularly in the US, whereas interest remained more limited in France and Britain. A comparative analysis of the rise of electroencephalography has certainly to account for such national differences, but the trajectory of the implementation of this technology calls for an investigation of local research cultures in order to identify units of productivity and to understand the dynamics along this trajectory.

Writing brains: tracing the psyche with the graphical method.

At the end of the 19th century, the graphic method kindled attempts to use it for investigating psychic processes. In Germany, Hans Berger took up this line of research, later to become the pioneer of electroencephalography (EEG). This trajectory of Berger's work is analyzed as an "enabling constraint" guiding him toward the EEG at a time when nobody else was pursuing this line of research and also causing serious methodological problems. In the epistemological perspective of this analysis, many of his problems extend beyond the local context of his work and point toward ambiguities surrounding the project to trace the psyche with the graphic method. From the mid-1930s, the EEG inspired ongoing attempts to decipher the specific meanings of these recordings, and large ensembles of machinery were mobilized, molding concepts of the psyche according to the results and the specifications of the graphic method.

[The search for a precise method of measurement in psychical experiments]. / Die Suche nach einer präzisen Messmethode für psychische Vorgänge.

In a series of three brief case studies, it is reconstructed how cognition and psychic activity were explored as energetic and economic transformations in a variety of experimental settings. 1. In the 1870s, the German psychiatrist Emil Kraepelin started his search for an objective measurement of cognitive performance in which he engaged over several decades. His investigations resulted in a graphic representation of cognitive efficiency, the "arbeitscurve", delineating the numbers of additions per time interval in close resemblance to representations of machine efficiency. 2. At the turn of the century, the American nutrition scientist and agronomist Wilbur Olin Atwater convinced himself in a series of precision measurements that the human motor was a so perfectly closed input-output system that he rejected any mental surplus in the form of cognitive energy transformations as contradictions to the principle of the conservation of energy. 3. At the beginning of the twentieth century and on the basis of Atwater's results, the German psychiatrist Hans Berger stipulated a special form of psychic energy for mediating between the principle of the conservation of energy and mental causality. Berger attempted to quantify psychic energy as one factor of brain metabolism. In the three cases of precision investigations into psychic life presented here, the experimental space of psychophysiology turned mental activity into a form of machine-like behavior.

[Mental work: the search for a precise way to measure psychic activity] / Kopfarbeit: die suche nach einer präzisen messmethode für psychische vorgänge.

Presents three brief case studies to show how cognition and psychic activity were explored as energetic and economic transactions in a variety of experimental settings. First, in the 1870's German psychiatrist Emil Kraepelin began a search for an objective measurement of cognitive performance in which he engaged for several decades. His investigations resulted in a graphic representation of cognitive efficiency, the Arbeitscurve, delineating numbers of additions per time interval in close resemblance to representations of machine efficiency. Second, at the turn of the century American nutrition scientist and agronomist Wilbur Olin Atwater convinced himself in a series of precision measurements that the human motor was a perfectly closed input-output system and that any mental surplus in the form of cognitive energy transformation did not count as contradictions to the principle of the conservation of energy. Third, at the beginning of the 20th century and on the basis of Atwater's results, German psychiatrist Hans Berger stipulated a special form of psychic energy for mediating between the principle of the conservation of energy and mental causality. Berger attempted to quantify psychic energy as one factor of brain metabolism. In the three cases of precision investigations into psychic life presented here, the experimental space of psychophysiology turned mental activity into a form of machine-like behavior.