ABSTRACT
Online supplemental material is available for this article.
Subject(s)
Tomography, X-Ray Computed , Vascular Diseases/diagnostic imaging , Aged , Arterial Occlusive Diseases/diagnostic imaging , Diagnosis, Differential , Fatal Outcome , Female , Humans , Lung Neoplasms/pathologyABSTRACT
Online supplemental material is available for this article.
Subject(s)
Gallbladder Diseases/diagnostic imaging , Gallbladder Diseases/surgery , Intestinal Volvulus/diagnostic imaging , Intestinal Volvulus/surgery , Tomography, X-Ray Computed/methods , Aged, 80 and over , Cholecystectomy/methods , Female , Gallbladder/diagnostic imaging , Gallbladder/surgery , HumansABSTRACT
OBJECTIVE: To evaluate complete tumor resection rate (primary objective), 30-day postoperative outcomes, and survival (secondary objectives) in patients with a hiatal hernia (HH) ≥5âcm (HH group) compared with those who did not have a HH or presented with a HH <5âcm (control group). BACKGROUND: HH is a risk factor for esophageal and junctional adenocarcinoma (EGJA). Its impact on the outcomes after EGJA surgery is unknown. METHODS: Among 367 patients who underwent surgery for EGJA, a HH was searched for on computerized tomography scan and barium swallow, with comparison between the HH (n = 42) and control (n = 325) groups. RESULTS: In the HH group, EGJAs exhibited higher rates of incomplete resection (50.0% vs 4.0%; P < 0.001), of pN3 stages (28.5% vs 10.1%; P = 0.002), and lower median survival (20.9 vs 41.0 mos; P = 0.001). After adjustment, a HH ≥5âcm was a predictor of incomplete resection (odds ratio 21.0, 95% confidence interval 9.4-46.8, P < 0.001) and a poor prognostic factor (hazard ratio 1.6, 95% confidence interval 1.1-2.5, P = 0.025). In the HH group, 30-day mortality was significantly higher in patients who received neoadjuvant radiotherapy (20.0% vs 0%; P = 0.040), which was related to greater cardiac and pulmonary toxicity. CONCLUSIONS: For the first time, we showed that a HH ≥5âcm is associated with a poor prognosis in patients who had surgery for EGJA, linked to greater incomplete resection and lymph node involvement. Neoadjuvant radiotherapy was associated with a significant toxicity in patients with a HH ≥5âcm.
Subject(s)
Adenocarcinoma/complications , Adenocarcinoma/surgery , Esophageal Neoplasms/complications , Esophageal Neoplasms/surgery , Esophagectomy , Hernia, Hiatal/complications , Adenocarcinoma/mortality , Adult , Aged , Aged, 80 and over , Case-Control Studies , Combined Modality Therapy , Esophageal Neoplasms/mortality , Female , Hospitalization , Humans , Male , Middle Aged , Neoplasm Staging , Survival Rate , Treatment Outcome , Young AdultABSTRACT
OBJECTIVE: The Response Evaluation Criteria in Solid Tumors (RECIST) can have limitations when used to evaluate local treatments for cancer, especially for liver malignancies treated by stereotactic body radiation therapy (SBRT). The aim of this study was to validate the relationship between the occurrence of lobulated enhancement (LE) and local relapse and to evaluate the utility of this relationship for predicting local progression. PATIENTS AND METHODS: Imaging data of 59 lesions in 46 patients, including 281 computed tomographic (CT) scans, were retrospectively and blindly reviewed by 3 radiologists. One radiologist measured the lesion size, for each CT and overall, to classify responses using RECIST threshold criteria. The second studied LE occurrence. A third radiologist was later included and studied LE occurrence to evaluate the interobserver consistency for LE evaluation. RESULTS: The mean duration of follow-up was 13.6 months. LE was observed in 16 of 18 progressive lesions, occurring before size-based progression in 50% of cases, and the median delay of LE detection was 3.2 months. The sensitivity of LE to predict progression was 89%, and its specificity was 100%. The positive predictive value was 100%, the negative predictive value was 95.3%, and the overall accuracy was 97%. The probability of local progression-free survival at 12 months was significantly higher for lesions without LE compared with all lesions: 0.80 (CI 95%: 0.65-0.89) versus 0.69 (CI 95%: 0.54-0.80), respectively. The overall concordance rate between the 2 readers of LE was 97.9%. CONCLUSION: Response assessment of liver metastases treated by SBRT can be improved by including LE. This study demonstrates the diagnostic and predictive utility of LE for assessing local progression at a size still eligible for local salvage treatment.
Subject(s)
Liver Neoplasms/surgery , Radiosurgery/methods , Adult , Aged , Aged, 80 and over , Chi-Square Distribution , Disease Progression , Female , Follow-Up Studies , Humans , Liver Neoplasms/diagnostic imaging , Liver Neoplasms/pathology , Liver Neoplasms/secondary , Male , Middle Aged , Neoplasm Recurrence, Local , Observer Variation , Retrospective Studies , Salvage Therapy , Sensitivity and Specificity , Statistics, Nonparametric , Tomography, X-Ray Computed , Young AdultABSTRACT
For ten years, a lot of advances have been achieved for the morphological exploration of the small intestine as well as with CT and MR enterography than with wireless capsule endoscopy. These investigations have renewed the approaches of different diseases that can affect the small intestine: tumors, especially sub-mucosal tumors (CT enterography), iron-deficiency anemia (capsule endoscopy) and follow-up of patients with Crohn's disease of the small intestine (MR enterography). Balloon enteroscopy may then allow therapeutic approach when needed (treatment of bleeding angiodysplasia).
