Subject(s)
Allergens/toxicity , Dermatitis, Allergic Contact/etiology , Dermatitis, Occupational/etiology , Glass , Adrenal Cortex Hormones/administration & dosage , Adult , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Allergic Contact/drug therapy , Dermatitis, Occupational/diagnosis , Dermatitis, Occupational/drug therapy , Humans , Industry , Male , Middle Aged , Patch TestsSubject(s)
Allergens/toxicity , Allyl Compounds/toxicity , Dermatitis, Allergic Contact/epidemiology , Dermatitis, Allergic Contact/etiology , Disulfides/toxicity , Food Hypersensitivity/epidemiology , Food Hypersensitivity/etiology , Garlic/toxicity , Adolescent , Adult , Aged , Asthma/chemically induced , Asthma/epidemiology , Child , Child, Preschool , Female , Humans , Infant , Male , Middle Aged , Patch Tests/statistics & numerical data , Retrospective Studies , Rhinitis/chemically induced , Rhinitis/epidemiology , Spain/epidemiology , Urticaria/chemically induced , Urticaria/epidemiologyABSTRACT
INTRODUCTION: Pemphigus vulgaris (PV) is a rare autoimmune bullous disease that affects the skin and mucosae, characterized by the presence of antibodies against desmoglein 3, that causes acantholisis and formation of intraepidermal blisters. Observation of PV cases in several members of the same family suggests the existence of genetic factors that contribute to susceptibility to suffer the disease. However, very few cases of familial PV have been described. Based on its autoimmune nature, many studies have found an association between PV and the HLA class II allele, specifically with the HLA-DRB1*0402 DQB1*0302 and HLA-DRB1*1401 DQB1*0503 haplotypes that bestows a significant risk of disease. OBJECTIVES: Study of three families with PV. PATIENTS AND METHODS: In this study, we present three families, with a total of 7 patients, diagnosed of familial PV. HLA antigens were determined with the PCR (polymerase chain reaction) technique in several members of these families. RESULTS: All the subjects affected were positive for HLA DR4 and HLA DR14. The fact that different families with PV are associated with identical haplotypes and that healthy siblings of the patients have the same haplotype is of special interest. CONCLUSION: These results support the concept of genetic predisposition in this rare disease.
Subject(s)
Pemphigus/genetics , Adult , Aged , Alleles , Female , Genetic Predisposition to Disease , HLA Antigens/analysis , HLA-DR Antigens/analysis , HLA-DR4 Antigen/analysis , Haplotypes , Humans , Male , Pedigree , Pemphigus, Benign Familial/genetics , Polymerase Chain ReactionSubject(s)
Mucinoses/pathology , Skin/pathology , Thorax , Dermatologic Surgical Procedures , Humans , Male , Middle Aged , Mucinoses/surgery , Treatment OutcomeABSTRACT
Dos mujeres de 31 y 27 años acudieron a nuestra consulta por presentar brotes de lesiones eritematovioláceas en cara superoexterna de muslos coincidiendo con las épocas más frías del año. Fueron diagnosticadas de eritrocianosis, entidad incluida en el amplio grupo de las criodermatosis, pero diferenciable tanto de la paniculitis por frío como de la perniosis (AU)