ABSTRACT
The aim of this study was to determine the effects of resistance training on the immunologic response, body composition, tumor necrosis factor-alpha (TNF-alpha) gene expression obtained from blood leukocytes, and the cytokines interleukin-6, TNF-alpha, and C-reactive protein (CRP), in the elderly women (mean age 63 ± 2 y). A randomized controlled trial was performed using a bi-set training method for eight weeks in nineteen elderly women. Peripheral blood samples were collected by puncture in pretraining (Pre) and posttraining (Post) moments. In the resistance training group, there was a statistically significant decrease from 38.43 ± 9.48 pg/mL to 11.76 ± 5.19 pg/mL (p=0.01) in the serum levels of interleukin-6. Considering serum levels of TNF-alpha, there was a statistically significant difference, comparing the resistance training group at Pre (66.27 ± 10.31 pg/mL) and Post (37.85 ± 9.05 pg/mL) moments (p=0.01). In molecular analysis of TNF-alpha gene expression, there was a statistically significant decrease (p=0.007) between Pre (0.010 ± 0.01 ng/ml) and Post (0.0002 ± 0.0001 ng/ml) moments. Among CRP data, in the resistance training group, there was a statistically significant reduction, between Pre (2.04 ± 0.32 mg/L) and Post (0.90 ± 0.22 mg/L) moments (p=0.001). In the Control group, there was no statistical significance between these two moments. Therefore, the resistance training demonstrated changes in the TNF-alpha gene expression in elderly women, as well as decreased serum levels of interleukin-6, TNF-alpha, and CRP. Such conditions may be related to immune modulation and anti-inflammatory effects, since resistance training releases cytokines, especially interleukin-6, which acts as a TNF-alpha antagonist during exercise.
ABSTRACT
Investigar a influência do treinamento de força (TF) sobre a concentração sorológica de resistina e pressão arterial de mulheres na pós-menopausa. Métodos: Estudo longitudinal, realizado na Universidade Federal de São Carlos, do qual participaram 23 mulheres sedentárias na pós-menopausa. O TF apresentou duração de 13 meses (dez/2008 a jan/2010), com duas sessões semanais, cada uma consistindo em três séries de 8-12 repetições máximas e um exercício para cada grupo muscular principal. Foi avaliada a força muscular máxima nos seguintes exercícios: supino, leg press 45° e flexão do cotovelo em pé. A concentração sérica de resistina foi determinada pelo método ELISA. No processamento estatístico, utilizou-se o ANOVA (com medidas repetidas) para comparar os momentos Pré, 6 meses e 13 meses (p<0,05). Para avaliar as correlações resistina × pressão arterial, resistina × força muscular e força × pressão arterial, utilizou-se o teste de correlação de Pearson. Resultados: As mulheres apresentaram o seguinte perfil antropométrico: 61,33±3,8 anos; estatura de 148,5±32,7 cm; massa corporal de 67,56±10,85 kg. O TF induziu a redução da concentração de resistina (30272,4±8100,1 versus 16350,6±2404,6 pg/mL) e pressão arterial sistólica (120,5±11,8 versus 115,8±1,6 mmHg), e o aumento da força muscular no leg press 45o (172,3±27,3 versus 348,6±40,8 kg), supino (31,9±4,1 versus 41,8±5,6 kg) e flexão docotovelo (21,0±2,4 versus 26,5±2,9 kg) após os 13 meses (p<0,05). Conclusão: Os resultados deste estudo revelaram que o TF a longo prazo aumenta a força muscular máxima, diminui a pressão arterial sistólica e os níveis séricos da resistina ? alterações fisiológicas benéficas para a redução do risco de doenças cardiovasculares em mulheres na pós-menopausa...
Investigate the influence of strength training (ST) on serum resistin levels and blood pressure of postmenopausal women. Methods: Longitudinal study conducted at the Federal University of São Carlos with twenty-three sedentary postmenopausal women. The ST lasted 13 months (Dec./2008 to Jan./2010) and consisted of two weekly sessions with three sets of 8-12 maximum repetitions and one exercise for each main muscle group. Maximum muscular strength was tested in the following exercises: bench press, 45° leg press, and standing arm curl. Serum resistin level was determined using the ELISA method. ANOVA (with repeated measures) was used for the comparisons between periods Pre-, 6 months and 13 months (p < 0.05); Pearson?s correlation test was used to evaluate the correlations between resistin × blood pressure, resistin × muscle strength and strength × blood pressure. Results: Women presented the following anthropometric profile: 61.33±3.8 years; height 148.5±32.7 cm; body mass 67.56±10.85 kg. The ST decreased resistin levels (30272.4 ± 8100.1 to 16350.6 ± 2404.6 pg/mL) and systolic blood pressure (120.5 ± 11.8 to 115.8 ± 1.6 mmHg), and increased muscular strength in the leg press 45o (172.3 ± 27.3 to 348.6 ± 40.8kg), bench press (31.9 ± 4.1 to 41.8 ± 5.6 kg) and arm curl (21.0 ± 2.4 to 26.5 ± 2.9 kg) after 13 months (p < 0.05). Conclusion: The results of this study revealed that long-term ST increases maximum muscular strength, decreases systolic blood pressure and serum resistin levels, which are beneficial physiological alterations that reduce the risk for cardiovascular diseases in postmenopausal women...
Investigar la influencia del entrenamiento de fuerza (EF) sobre la concentración serológica de resistina y presión arterial em mujeres posmenopausia. Métodos: Estudio longitudinal realizado en la Universidad Federal de São Carlos en el cual participaron 23 mujeres sedentarias posmenopausia. El EF tuvo duración de 13 meses (diciembre de 2008 a enero de 2010) con dos sesiones semanales, siendo cada sesión constituida de tres series de 8-12 repeticiones máximas y un ejercicio para cada grupo muscular principal. Fue evaluada la fuerza muscular máxima en los siguientes ejercicios: supino, leg press 45° y flexión de codo de pie. La concentración sérica de resistina fue determinada por el método ELISA. En el procesamiento estadístico se utilizo ANOVA (con medidas repetidas) para las comparaciones entre los momentos pre, 6 meses y 13 meses (p < 0,05); se utilizó La prueba de correlación de Pearson para evaluar las correlaciones entre resistina × presión arterial, resistina × fuerza muscular y fuerza × presión arterial. Resultados: Las mujeres presentaron el siguiente perfil antropométrico: 61,33±3,8 años; altura 148,5±32,7 cm; masa corporal 67,56±10,85 kg. El EF llevó a La reducción de la concentración de resistina (30272,4±8100,1 versus 16350,6±2404,6 pg/mL) y presión arterial sistólica (120,5±11,8 versus 115,8±1,6 mmHg) y aumento de fuerza muscular en el leg press 45º (172,3±27,3 versus 348,6±40,8 kg), supino (31,9±4,1 versus 41,8±5,6 kg) y flexión de codo (21,0±2,4 versus 26,5±2,9 kg) después de los 13 meses (p < 0,05). Conclusión: Los resultados del estudio revelaron que el EF a largo plazo aumenta la fuerza muscular máxima, disminuye la presión arterial sistólica y los niveles séricos de la resistina, alteraciones fisiológicas benéficas para la reducción del riesgo de enfermedades cardiovasculares em mujeres posmenopausia...
Subject(s)
Humans , Arterial Pressure , Resistance Training , Resistin , WomenABSTRACT
The aim of the present study was to compare the responses of blood pressure, heart rate, and rate-pressure product of hypertensive women using beta-blockers with healthy controls during resistance exercise (by the end of the concentric phase of the contractions) and in the postexercise period (5 and 30 minutes after). Ten untrained normotensive women (N) and 10 mildly hypertensive females receiving 40 mg/day of propanolol (H) were selected. Three sets of 10 repetitions at 80% of 10 repetitions maximum with 30 s rest interval were performed on the leg press exercise. The H group exhibited lower systolic blood pressure after the second set compared with N. Heart rate and rate-pressure product were lower in H in all analyzed periods compared with N. Propanolol attenuates the cardiovascular response to a leg press resistance exercise in mildly hypertensive women.
