[Therapy of perinatal brain injury outcomes: results of a multicenter double-blind placebo-controlled randomized study of tenoten for children (liquid dosage form)]. / Terapiya posledstvii perinatal'nogo porazheniya tsentral'noi nervnoi sistemy: rezul'taty mnogotsentrovogo dvoinogo slepogo platsebo-kontroliruemogo randomizirovannogo klinicheskogo issledovaniya zhidkoi lekarstvennoi formy preparata Tenoten detskii.

OBJECTIVE: To evaluate the efficacy and safety of tenoten for children (a novel liquid pediatric formulation) in the treatment of perinatal brain injury (PBI) outcomes. MATERIAL AND METHODS: The multicenter double-blind placebo-controlled randomized trial enrolled 184 children (aged 29 days-9 months) with the total score 12-27 according to Djurba-Mastukova scale and the level of physical development 25-75 centiles. Patients were randomized into tenoten (10 drops per day) and placebo groups. Treatment period was 12 weeks ± 5 days. Percentage of patients with ≥4 points improvement according to Djurba-Mastukova scale (responder rate) was used as a primary efficacy endpoint. RESULTS AND CONCLUSION: Patients in the tenoten group had a significant result on primary efficacy endpoint: 77.5% of participants responded to therapy (p=0.02 vs. placebo). In addition, the safety of tenoten for children in the treatment of PBI outcomes is shown. Tenoten for children (a novel liquid pediatric formulation) has been shown to be an effective medication in treatment of PBI outcomes that helps to achieve therapeutic results with minimal side-effects, good tolerability and the high level of adherence to therapy.

[Leber's hereditary optic neuropathy and epilepsy: a case report]. / Nasledstvennaya atrofiya zritel'nykh nervov Lebera i epilepsiya: opisanie klinicheskogo nablyudeniya.

A clinical case of a young man with rapid bilateral visual impairment developed 2 months after the onset of generalized convulsive seizures is presented. The replacement of valproate to levetiracetam led to the remission of seizures, but the prognosis for vision remains poor, particularly given the pessimistic results of optical coherence tomography (OCT).

[Methodological approaches to developing programs on children's health management]. / Metodicheskie podkhody k razrabotke programm po upravleniiu zdorov'em detskogo naseleniia.

The development of specific plants of action to manage the health of different population groups should be based on the results of pilot studies whose purpose is to obtain information that is useful and understandable for decision makers. To improve the health of children living in the town of Gai, Orenburg Region, which is one of the most pressing problems for the town, 100 potential risk factors of frequent diseases among preschool children were analyzed. It has been shown that the frequent occurrence of diseases may be due to the influence of a complex of biomedical and sociohygienic factors. The use of multifactorial analysis permits one not only to assess a role of each factor, but to predict the effectiveness of different preventive measures. The findings yielded a scientifically grounded interdepartmental program for children's health improvement.

[Characteristics of the strategy of intensive care of unconscious children]. / Osobennosti reanimatsionnoi taktiki u detei v bessoznatel'nom sostoianii.

Three major groups can be distinguished among children hospitalized in resuscitation and intensive care wards in a state of unconsciousness: patients with bacterial meningitis and meningoencephalitis, viral meningoencephalitis, and noninfectious involvement of the NCS. Common strategy of treatment of these patients is characterized by some specific features: etiotropic antibiotic therapy in group 1 patients, antiviral drugs in group 2, and mainly symptomatic measures in group 3. Immunotherapy used in each of these groups is substitute in group 1, immunomodulating and immunostimulating in group 2 and even more so in group 3. Better results in group 1 are due to highly effective etiotropic antibiotics and drugs.