Simultaneous spectrophotometric estimation of haloperidol and trihexyphenidyl in tablets.

The combination of haloperidol and trihexyphenidyl is a dosage form to be used as antidyskinetic agent. Literature revealed that there is no single method for the simultaneous estimation of these drugs in tablet dosage form, which prompted us to develop a simple, rapid, accurate, economical and sensitive spectrophotometric method. The simultaneous estimation method is based on the principle of additivity of absorbance, for the determination of haloperidol and trihexyphenidyl in tablet formulation. The absorption maxima of the drugs were found to be at 245.0 nm and 206.0 nm respectively for haloperidol and trihexyphenidyl in methanol and 0.1N HCl (90:10). The obeyance of Beer Lambert's law was observed in the concentration range of 2.5-12.5 µg/ml for haloperidol and 1.0-5.0 µg/ml for trihexyphenidyl. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies.

A retrospective study of etiopathological and preventive factors in a burns unit in Saudi Arabia.

A 10-bed state-of-the-art burns unit was commissioned at King Fahd Specialist Hospital, Buraidah, Al-Qassim and the first 90 cases admitted to the unit over an 18-month period were analysed. The mean age (+/-SD) was 14.9 (+/-1.5) years with a range of 6 months-55 years. Fifty-one per cent were males, 52.2 per cent were children under 12 years of age and of these 85.1 per cent were under 5 years of age. Scalds and flames accounted for 90 per cent of the burns. Domestic burns formed the majority of cases, 64 (71 per cent), and most patients were admitted within the first 24 h (76 per cent). The mean (+/-SE) of the total body surface area (TBSA) was 23 per cent (+/-2.4) with a range of 3-98 per cent. The mean hospital stay for the whole group was 16.4 days. Overall mortality was five patients (5.6 per cent) while the mortality in critical burns was 14.3 per cent. TBSA was found to be the main factor influencing mortality. This study highlights the important factors that affect the outcome in this unit. Factors that can improve the morbidity and mortality rates in patients are highlighted. The study also reveals certain patterns and etiological factors in the Qassim region. Prevention by education through a national campaign remains the keystone in reducing the incidence of burns particularly in children and the maximization of resources.

Epidemiology of facial clefts in the central province of Saudi Arabia.

A pilot study collecting data both retrospectively and prospectively covering a span of 4 years (January 1989 to December 1992) was carried out at King Fahd Specialist Hospital, Al-Gassim, Saudi Arabia. The aim was to study the epidemiology of facial clefts in the exclusively Saudi population. A total of 137 cases were studied. This study gives the highest reported incidence of clefts (2.19 per 1000 live births) with some distinct differences in the pattern of clefts as compared to other documented studies.

Potassium iodate and its comparison to potassium iodide as a blocker of 131I uptake by the thyroid in rats.

Potassium iodide is the preferred thyroid blocker for personnel handling radioiodine and is recommended as a prophylaxis for the population in the near-field of a nuclear reactor which would be likely to be exposed to radioiodine in an accidental breach of containment. However, in hot and humid climates, this hygroscopic chemical has a poor shelf life due to hydrolytic loss of iodine vapors. On the other hand, another iodine-rich salt, potassium iodate (KIO3), is quite stable and has a much longer shelf life. The present study compares potassium iodide and KIO3 as thyroid blockers and examines the appropriate time at which they should be administered in case of radioiodine exposure. Either of the two were given in recommended dosage (100 mg stable iodine per 70 kg body weight) at -2, 0, +2, +4, +6, and +8 h after administration of tracer quantities of radioiodine (131I) to age-, weight-, and sex-matched rats. 131I uptake in thyroid was measured 24 h after its administration in the experimental animals and compared with placebo administered controls. Results suggest that KIO3 is as effective a thyroid blocking agent as potassium iodide. In comparison to controls, 24-h thyroid uptake of 131I can be substantially reduced if potassium iodide or KIO3 is given to the animals within 2-4 h after exposure to 131I. Another noteworthy observation is that KIO3 is effective even at 8 h when administered at twice the usual dosage in comparison to the single dose, which does not show appreciable thyroid blocking properties after 8 h.

99mTc-sodium pertechnetate permeation into cerebrospinal fluid.

The integrity of the blood-brain barrier may be reflected by the blood and cerebrospinal fluid (CSF) if these two compartments are sampled at an appropriate interval after the administration of certain substances. After reading through the controversial literature, this study was undertaken to determine the frequency with which 99mTc-sodium pertechnetate entered the CSF to an abnormal extent, and to see whether this was related to any particular pathology. The plasma-to-CSF ratios were determined in 51 patients 4 hours following the intravenous administration of 0.5-10 mCi 99mTc-sodium pertechnetate. In 23 patients with active CNS tuberculosis, the mean value of the pertechnetate plasma-to-CSF ration was 32.12. In contradistinction, the plasma-to-CSF pertechnetate in 28 nontuberculous subjects was considerably higher (144.63). For the purpose of correlation, a 82Br partition test was also done on each subject 48 hours following the oral administration of NH82Br. The 48-hour study in each of these cases was generally in agreement with the pertechnetate studies: the plasma-to-CSF ratio mean value was 1.25 in patients with active CNS tuberculosis, while for the nontuberculous patients it was 3.32.