Homeopathy-A lively relic of the prescientific era.

Homeopathy was first postulated by the German physician Samuel Hahnemann in 1796 and 220 years later homeopathy is the most popular and widespread alternative medicine. Partly, it is also part of the national healthcare and insurance systems but homeopathy is not without controversy within the medical and healthcare community. Its implausible basic assumptions, some of which contradict natural laws, do not lead us to expect that its remedies have any specific effect. In fact, there is no study or systematic review to date that reliably certifies homeopathy to have an effect beyond the placebo effect and other context effects. In this respect it must be disconcerting how widely homeopathy is applied and represented in therapeutic practice. It indeed claims a role within scientific (evidence-based) medicine but cannot substantiate this claim. It displays clear characteristics of pseudoscience [1]. This implies a lot of problems, such as misleading people and tackling medical ethics up to scientific publication practices. Furthermore, it turns out that quite a few people do not know exactly what homeopathy is, which may lead them to make wrong decisions for their personal health. This article summarizes the information about homeopathy and its problematic implications and serves as a general introduction to this topic and its unacceptable role in today's medicine.The medical irrelevance of the sham method of homeopathy has been proven with more than sufficient probability [2]. As a major testimonial, the statement "Homeopathic products and practices" of the European (EASAC 2017) can be regarded. The primary aim of this brief report is therefore not to take another look at homeopathy from a medical scientific perspective, but rather focus attention on the implications of the still continuous and largely uncritically accepted existence of this method in medical practice, in the medical scientific sphere and in the judgement of the general public.

Malaria & mRNA Vaccines: A Possible Salvation from One of the Most Relevant Infectious Diseases of the Global South.

Malaria is one of the most dangerous infectious diseases in the world. It occurs in tropical and subtropical regions and affects about 40% of the world´s population. In endemic regions, an estimated 200 million people contract malaria each year. Three-quarters of all global deaths (about 600 per year) are children under 5 years of age. Thus, malaria is one of the most relevant tropical and also childhood diseases in the world. Thanks to various public health measures such as vector control through mosquito nets or the targeted use of insecticides as well as the use of antimalarial prophylaxis drugs, the incidence has already been successfully reduced in recent years. However, to reduce the risk of malaria and to protect children effectively, further measures are necessary. An important part of these measures is an effective vaccination against malaria. However, the history of research shows that the development of an effective malaria vaccine is not an easy undertaking and is associated with some complications. Research into possible vaccines began as early as the 1960s. However, the results achieved were rather sobering and the various vaccines fell short of their expectations. It was not until 2015 that the vaccine RTS,S/AS01 received a positive evaluation from the European Medicines Agency. Since then, the vaccine has been tested in Africa. However, with the COVID-19 pandemic, there are new developments in vaccine research that could also benefit malaria research. These include, among others, the so-called mRNA vaccines. Already in the early 1990s, an immune response triggered by an mRNA vaccine was described for the first time. Since then, mRNA vaccines have been researched and discussed for possible prophylaxis. However, it was not until the COVID-19 pandemic that these vaccines experienced a veritable progress. mRNA vaccines against SARS-CoV-2 were rapidly developed and achieved high efficacy in studies. Based on this success, it is not surprising that companies are also focusing on other diseases and pathogens. Besides viral diseases, such as influenza or AIDS, malaria is high on this list. Many pharmaceutical companies (including the German companies BioNTech and CureVac) have already confirmed that they are researching mRNA vaccines against malaria. However, this is not an easy task. The aim of this article is to describe and discuss possible antigens that could be considered for mRNA vaccination. However, this topic is currently still very speculative.

Black Salve (or escharotics). A picture about an unorthodox medical preparation in oncology.

Alternative medicine methods and treatments enjoy great popularity. However, many users fail to recognise the dangers associated with these methods. One of these is called Black Ointment or Black Salve. Oncologists and attending physicians should be aware of alternative medical methods such as these and be in a position to provide appropriate advice, intervention, if necessary, at any time when counselling patients in difficult situations.

Mytilicola orientalis.

Neozoa are invasive species that enter faunal communities as new species. Not infrequently, they pose a threat to local ecosystems. Climate change could further promote these developments or favor neozoa. Thus, they represent a relevant threat in the future. One of these neozoa is the copepod parasite Mytilicola orientalis. This parasite originates from Asia and infects a wide variety of bivalves like mussels and oysters. However, as an invasive species, it can be found more and more frequently in Europe, especially in the North and Baltic Seas. There, M. orientalis poses a real threat to mussels in aquaculture and thus also to the local economy.

[Malarial antigens in the era of mRNA vaccines]. / Malaria-Antigene in der Ära der mRNA-Impfstoffe: Mögliche Rettungen vor einer der relevantesten und gefährlichsten Kinderkrankheiten des Globalen Südens.

Even in the early 1990s, an immune response triggered by an mRNA vaccine was described for the first time. Since then, mRNA vaccines have been researched and discussed for possible prophylaxis; however, it was not until the COVID-19 pandemic that these vaccines experienced a real boom. The first mRNA vaccines were licensed against SARS-CoV­2 and showed great success. It is therefore not surprising that manufacturers are also focusing on other diseases and pathogens. Besides viral diseases, such as influenza and AIDS, malaria is high on this list. Many pharmaceutical companies (including the German companies BioNTech and CureVac) have already confirmed that they are researching mRNA vaccines against malaria. Yet developing a working vaccine against malaria is no easy feat. Research on possible vaccines has been going on since the 1960s. The results have been rather sobering. It was not until 2015 that the vaccine RTS,S/AS01 received a positive evaluation from the European Medicines Agency. Since then, the vaccine has been tested in Africa.

Toxoplasma gondii in Australian macropods (Macropodidae) and its implication to meat consumption.

Toxoplasma gondii is a worldwide occurring apicomplexan parasite. Due to its high seroprevalence in livestock as well as in game animals, T. gondii is an important food-borne pathogen and can have significant health implications for humans as well as for pets. This article describes the prevalence of T. gondii in free-ranging macropods hunted for consumption. All hunted macropod species (commercial as well as non-commercial hunt) show a positive seroprevalence for T. gondii. This seroprevalence is influenced by various factors, such as sex or habitat. Furthermore, the parasite shows a high level of genetic variability in macropods. Genetically variable strains have already caused outbreaks of toxoplasmosis in the past (Canada and the US). These were attributed to undercooked game meat like venison. Despite this risk, neither Australia nor New Zealand currently have food safety checks against foodborne pathogens. These conditions scan pose a significant health risk to the population. Especially, since cases of toxoplasmosis have already been successfully traced back to insufficiently cooked kangaroo meat in the past.

[Toxoplasma gondii-Current drugs and future vaccines against an underestimated protozoan infection]. / Toxoplasma gondii ­ gegenwärtige Arzneimittel und zukünftige Impfstoffe gegen eine unterschätzte Protozoonose.

Toxoplasma gondii is a unicellular organism of the Apicomplexa that occurs worldwide and is therefore a close relative of the malaria pathogen Plasmodium. As T. gondii infests every warm-blooded vertebrate species as an intermediate host and has a very high prevalence worldwide, toxoplasmosis is one of the most important international foodborne diseases. Potential vaccines (human as well as veterinary) play a crucial role in controlling this disease.

Bund katholischer Ärzte: Homeopathic Conversion Therapists in 21st Century Germany.

Even in modern Germany of the 21st century there is still homophobia and other intolerances towards different sexualities and genders. These are also evident in the presence of so-called conversion therapies, which are still offered although there are already legal efforts. Among those groups, the Bund katholischer Ärzte (Association of Catholic Doctors) is a unique curiosity. Although this group is no longer really active, it is currently moving into the German focus again due to criminal charges and reporting in the tabloid press. The aim of this publication is to bring the Bund katholischer Ärzte not only into a more scientific but also into a more international focus. Furthermore, it is an ideal example to show what strange effects homophobia can produce.