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Ter Arkh ; 82(6): 53-5, 2010.
Article in Russian | MEDLINE | ID: mdl-20731113

ABSTRACT

The paper discusses the problems of the diagnosis and treatment of Wegener's granulomatosis, the most common anti-neutrophil cytoplasmic antibody-associated systemic vasculitis. It describes a clinical case in which the administration of rituximab could achieve remission of severe Wegener's granulomatosis in a young man having numerous adverse reactions associated with the long-term use of high- and average-dose glucocorticoids and nonselective immunosuppressive agents. A place of rituximab in current drug therapy for Wegener's granulomatosis is shown.


Subject(s)
Antibodies, Monoclonal, Murine-Derived/therapeutic use , Granulomatosis with Polyangiitis/diagnosis , Granulomatosis with Polyangiitis/drug therapy , Immunologic Factors/therapeutic use , Adult , Antibodies, Monoclonal, Murine-Derived/administration & dosage , Humans , Immunologic Factors/administration & dosage , Male , Rituximab , Severity of Illness Index , Treatment Outcome
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