Linking policies and regulations to sustainable finance for the promotion of urban agriculture: Evidence from micro and small businesses.

Urban agriculture is closely tied to several of the Sustainable Development Goals. It can play a critical role in helping to achieve these goals by promoting sustainable food production and consumption, reducing greenhouse gas emissions, and creating more sustainable cities. It is also considered a pathway for overcoming food security in urban areas. However, this needs to be integrated with policies and regulations supported by sustainable finance. Due to COVID-19, conflict, and lack of infrastructure in Ethiopia, several challenges must be addressed to promote urban agriculture to aid food security. Hence, this study is conducted to examine how government policies and regulations promote urban agriculture through sustainable finance in Ethiopia. The study employed both an explanatory research design and a mixed research approach. Multi-stage sampling techniques that include (Simple random sampling techniques and judgmental sampling were used. The data was collected from selected micro and small enterprises engaged in urban agriculture. The structural and measurement model is estimated with the help of smart-pls software version 4. The study's finding implies that government policies and regulations have an insignificant effect on urban agriculture. At the same time, the study finding implies that sustainable finance has an important mediating role between urban agriculture and government policies. Hence, the impact of government policies and regulations on urban agriculture is found to have an indirect effect. Based on the study's findings, the study recommends that all stakeholders promote innovation and entrepreneurship that promote urban agriculture through sustainable finance.

Green building energy: Patents analysis and analytical hierarchy process evaluation.

In the dynamic sphere of building energy systems, this study explores advancements in energy integration, storage technologies, management practices, and occupant behavior, assessing sustainable energy practices, including emerging technologies like fuel cells and energy storage systems. It underscores the significance of efficient energy management, considering both renewable and conventional energy mechanisms. The study comprises four key strata: (i) a thorough literature review of recent energy trends, (ii) a comparative study of global energy patents using the World Intellectual Property Organization (WIPO) database, (iii) a comprehensive analysis of building-energy patents, and (iv) expert-guided Analytic Hierarchy Process (AHP) evaluation. These realms encompass five primary sources: (i) energy-efficient building design, (ii) intelligent building automation, (iii) optimizing energy systems integration, (iv) energy storage, and (v) energy management and optimization. Findings reveal energy storage's dominance, with water energy storage and emerging hydrogen technology leading the trajectory. Global energy patent scrutiny underscores China, the United States, and Japan as influential players in optimizing energy markets. The research shapes energy futures, identifies gaps, and drives sustainable energy practices within the built environment, serving as a compass for policymakers and researchers.

PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle.

The role of Peroxisome proliferator-activated receptor-gamma coactivator alpha (PGC-1α) in fat metabolism is not well known. In this study, we compared the mechanisms of muscle-specific PGC-1α overexpression and exercise-related adaptation-dependent fat metabolism. PGC-1α trained (PGC-1α Ex) and wild-trained (wt-ex) mice were trained for 10 weeks, five times a week at 30 min per day with 60 percent of their maximal running capacity. The PGC-1α overexpressed animals exhibited higher levels of Fibronectin type III domain-containing protein 5 (FNDC5), 5' adenosine monophosphate-activated protein kinase alpha (AMPK-α), the mammalian target of rapamycin (mTOR), Sirtuin 1 (SIRT1), Lon protease homolog 1 (LONP1), citrate synthase (CS), succinate dehydrogenase complex flavoprotein subunit A (SDHA), Mitofusin-1 (Mfn1), endothelial nitric oxide synthase (eNOS), Hormone-sensitive lipase (HSL), adipose triglyceride lipase (ATGL), G protein-coupled receptor 41 (GPR41), and Phosphatidylcholine Cytidylyltransferase 2 (PCYT2), and lower levels of Sirtuin 3 (SIRT3) compared to wild-type animals. Exercise training increased the protein content levels of SIRT1, HSL, and ATGL in both the wt-ex and PGC-1α trained groups. PGC-1α has a complex role in cellular signaling, including the upregulation of lipid metabolism-associated proteins. Our data reveals that although exercise training mimics the effects of PGC-1α overexpression, it incorporates some PGC-1α-independent adaptive mechanisms in fat uptake and cell signaling.

The Circulating Level of Klotho Is Not Dependent upon Physical Fitness and Age-Associated Methylation Increases at the Promoter Region of the Klotho Gene.

(1) Background: Higher levels of physical fitness are believed to increase the physiological quality of life and impact the aging process with a wide range of adaptive mechanisms, including the regulation of the expression of the age-associated klotho (KL) gene and protein levels. (2) Methods: Here, we tested the relationship between the DNA methylation-based epigenetic biomarkers PhenoAge and GrimAge and methylation of the promoter region of the KL gene, the circulating level of KL, and the stage of physical fitness and grip force in two groups of volunteer subjects, trained (TRND) and sedentary (SED), aged between 37 and 85 years old. (3) Results: The circulating KL level is negatively associated with chronological age in the TRND group (r = -0.19; p = 0.0295) but not in the SED group (r = -0.065; p = 0.5925). The age-associated decrease in circulating KL is partly due to the increased methylation of the KL gene. In addition, higher plasma KL is significantly related to epigenetic age-deceleration in the TRND group, assessed by the biomarker of PhenoAge (r = -0.21; p = 0.0192). (4) Conclusions: The level of physical fitness, on the other hand, does not relate to circulating KL levels, nor to the rate of the methylation of the promoter region of the KL gene, only in males.

No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging.

Cellular senescence is greatly accelerated by telomere shortening, and the steps forward in human aging are strongly influenced by environmental and lifestyle factors, whether DNA methylation (DNAm) is affected by exercise training, remains unclear. In the present study, we investigated the relationships between physiological functions, maximal oxygen uptake (VO2max), vertical jump, working memory, telomere length (TL) assessed by RT-PCR, DNA methylation-based estimation of TL (DNAmTL), and DNA methylation-based biomarkers of aging of master rowers (N = 146) and sedentary subjects (N = 95), aged between 37 and 85 years. It was found that the TL inversely correlated with chronological age. We could not detect an association between telomere length and VO2max, vertical jump, and working memory by RT-PCR method, while these physiological test results showed a correlation with DNAmTL. DNAmGrimAge and DNAmPhenoAge acceleration were inversely associated with telomere length assessed by both methods. It appears that there are no strong beneficial effects of exercise or physiological fitness on telomere shortening, however, the degree of DNA methylation is associated with telomere length.

Penal Sanctioning of Zoophilia in Light of the Legal Status of Animals-A Comparative Analysis of Fifteen European Countries.

The criminal legislation regarding zoophilia and the legal status of animals were examined in 15 European countries. With regard to zoophilia, answers to the following questions were sought: are sexual acts performed with animals and the possession and distribution of animal pornography criminally punishable? Several aspects of the legal status of animals were examined including: (1) is the protection of individual animals included in the constitution, (2) do animals have a special status beyond mere objects, (3) can we find specific legislative provisions that explicitly state that animals are not simply things, and (4) does the legal system also take the "dignity" of animals into consideration. The assessment of zoophilia and the legal status of animals resulted in two country rankings, which the authors compared with each other. The correlation was not significant (p = 0.3147). At the same time, countries with differentiated criminal legislation for zoophilia were also 3.62 times more likely to rank higher in terms of the legal status of animals. The Swiss regulations are exceptional in both respects, while at the other end of the list, Italy does not have specific legislative provisions for either aspect.

The COVID-19 pandemic and physical activity.

The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health, economy, and lifestyle. Although the virus usually first invades and infects the lung and respiratory track tissue, in extreme cases, almost all major organs in the body are now known to be negatively impacted often leading to severe systemic failure in some people. Unfortunately, there is currently no effective treatment for this disease. Pre-existing pathological conditions or comorbidities such as age are a major reason for premature death and increased morbidity and mortality. The immobilization due to hospitalization and bed rest and the physical inactivity due to sustained quarantine and social distancing can downregulate the ability of organs systems to resist to viral infection and increase the risk of damage to the immune, respiratory, cardiovascular, musculoskeletal systems and the brain. The cellular mechanisms and danger of this "second wave" effect of COVID-19 to the human body, along with the effects of aging, proper nutrition, and regular physical activity, are reviewed in this article.