ABSTRACT
Fibromas often occur orally and are typically due to trauma to underlying connective tissue resulting in tissue enlargement. To prevent continuing trauma to the tissue, excision may be recommended, and biopsy is often indicated for these masses to confirm their diagnosis and to rule out a potential malignant cause. This article presents a case report in which a Er,Cr:YSSG laser was utilized for excision of an oral fibroma. This approach enabled excellent tissue response compared to the use of a scalpel or monopolar electrosurgery, with minimal patient postoperative discomfort and improved healing.
Subject(s)
Fibroma , Laser Therapy , Mouth Neoplasms , Humans , Lasers , Mouth MucosaABSTRACT
The concept of pseudomelanocytic nests has been recently described in the dermatology literature. To our knowledge, this entity has yet to be published in the oral pathology literature. We report 2 cases with features of pseudomelanocytic nests. In both instances, nests of cells suspicious for melanocytes were observed. Interpretation of melan-A was negative. Both cases showed strong and diffuse immunoreactivity of the nested cells to CD68. This immunohistochemical staining pattern is most consistent with a melanophage identity. Pseudomelanocytic nests are a recently described entity that represents a potential diagnostic pitfall. Distinguishing pseudomelanocytic nests from an authentic atypical melanocytic proliferation can be challenging and is important for appropriate patient management. Clinicopathologic correlation with cautious interpretation of immunohistochemistry may be necessary to arrive at the correct diagnosis. These cases represent the first reports of pseudomelanocytic nests in the oral pathology literature.
Subject(s)
Gingiva/pathology , Melanocytes/pathology , Aged , Biopsy , Diagnosis, Differential , Humans , Immunohistochemistry , MaleABSTRACT
Anaplastic large cell lymphoma (ALCL), a subgroup of T-cell non-Hodgkin's lymphoma, is an uncommon tumor exhibiting CD30 positivity and a characteristic immunophenotypic profile. Histologically, ALCL is characterized by the proliferation of large, anaplastic lymphoid cells with eccentric horseshoe- or kidney-shaped nuclei and one or more prominent nucleoli. Rare cases have been cited in the literature of ALCL presenting primarily in the oral cavity. The purpose of this article was to present 2 instructive cases of CD30+, anaplastic lymphoma kinase-negative ALCL with oral and systemic involvement.
Subject(s)
Lymphoma, Large-Cell, Anaplastic/diagnosis , Mouth Neoplasms/diagnosis , Tongue Neoplasms/diagnosis , Adult , Biopsy , Diagnosis, Differential , Female , Humans , Ki-1 Antigen/metabolism , Lymphoma, Large-Cell, Anaplastic/metabolism , Lymphoma, Large-Cell, Anaplastic/pathology , Magnetic Resonance Imaging , Male , Middle Aged , Mouth Neoplasms/metabolism , Mouth Neoplasms/pathology , Radiography, Thoracic , Tomography, X-Ray Computed , Tongue Neoplasms/metabolism , Tongue Neoplasms/pathologyABSTRACT
Atypical odontalgia is a commonly misdiagnosed condition that frequently leads to unnecessary dental treatments such as extraction and endodontic therapy. These treatments often worsen the pain. Despite greater recognition and understanding of this condition, proper diagnosis and treatment remains a challenge. It is believed that atypical odontalgia is a neuropathic condition. This article updates the current understanding of the etiology and pathophysiology of atypical odontalgia, and provides appropriate diagnostic and management approaches for this condition.
Subject(s)
Chronic Pain/diagnosis , Toothache/diagnosis , Chronic Pain/therapy , Diagnosis, Differential , Humans , Toothache/etiology , Toothache/therapy , Treatment Outcome , Trigeminal Neuralgia/diagnosisSubject(s)
Glomus Tumor/pathology , Lip Neoplasms/pathology , Actins/analysis , Adult , Antigens, CD34/analysis , Glomus Tumor/blood supply , Glomus Tumor/chemistry , Humans , Immunohistochemistry , Lip Neoplasms/blood supply , Lip Neoplasms/chemistry , Male , Platelet Endothelial Cell Adhesion Molecule-1/analysis , Vimentin/analysisABSTRACT
BACKGROUND: Toxic epidermal necrolysis (TEN) is a rare and potentially fatal adverse dermatologic reaction, often secondary to drug intake. METHODS AND RESULTS: We report a case of an adult male who developed TEN that was complicated by a sepsis-induced coma lasting a period of 3 months. Although the patient eventually recovered, severe oral mucosal involvement during the course of disease resulted in frenum-like fibrotic bands that connected movable oral mucosa (tongue and lips) to attached oral mucosa (gingiva). This complication was painful and also affected his ability to speak and maintain adequate oral hygiene, requiring surgical intervention to restore structure and function. CONCLUSIONS: This oral manifestation in relation to TEN is rarely reported in the literature and represents a preventable complication.
