ABSTRACT
Data on peroral application of new peptide origin immunocorrector from nervous tissue of hydrobionts are cited. It has been established that immunological gangliin activity, perorally introduced, is close to that being applied parenterally. This drug comprises a soft immunocorrector that is expressed by humoral and cellular factor strengthening of immunity, increasing induces of phagocynosis of PMNC and sells SMPh. Peroral gangliin introduction protects 50-60% of mice from fatal coli-infection. Gangliin availability to be taken perorally opens the door to its wide application as food addition.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Neuropeptides/therapeutic use , Peptides/therapeutic use , Administration, Oral , Animals , Antibody Formation/drug effects , Drug Evaluation, Preclinical , Guinea Pigs , Hematologic Tests , Immunity, Cellular/drug effects , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Rats , Rats, WistarABSTRACT
Authors had received and investigated on experiment milk medical and prophylactic products (milk and kefir) with addition peptide, obtained from nervous tissue of squids. It has been established that addition of gangliin to the milk and kefir causes stimulation cellular and humoral factors of immunity answer at laboratory animals. Medical and prophylactic milk products with gangliin return to the normal state reduced immunity indexes of the mice with experimental immunodeficits.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Dairy Products , Food, Fortified , Milk , Peptides/therapeutic use , Animals , Antibody Formation , Immune Tolerance , Male , Mice , Mice, Inbred CBA , Spleen/immunologyABSTRACT
Gangliin (tinrostim), a novel peptide isolated from the nervous tissue of the food mollusks, was investigated with respect to its effect on the cells of the system of the mononuclear phagocytes. It was shown to have a high protective action in some experimental infections. One of the main mechanisms of the gangliin action was the increase of the functional activity of the cells of the system of the mononuclear phagocytes. It was demonstrated that gangliin induced a decrease in the activity of 5'-nucleotidase and increased the absorption and digestive functions of the macrophage.
Subject(s)
Ganglia, Invertebrate/chemistry , Ganglia, Sensory/chemistry , Macrophages/drug effects , Mollusca/chemistry , Neuropeptides/pharmacology , Visual Pathways/chemistry , Animals , Mice , Mice, Inbred BALB C , Mice, Inbred C57BL , Mice, Inbred CBA , Salmonella Infections, Animal/prevention & controlABSTRACT
The data on the effect of a peptide from the squid optic ganglia named gangliin on some parameters of animal natural resistance are presented. It was shown that the prophylactic use of the peptide in mice 24 hours before their contamination with the lethal dose of E. coli protected 40 to 60 per cent of the animals from death. Gangliin accelerated elimination of E. coli from the host and increased the absorptive and digestive activity of the macrophages and polymorphonuclear leukocytes. With the use of gangliin it was possible to correct the phagocytosis defects in infectious processes having the phagocytic protection mechanism. Moreover, gangliin was supposed to be efficient in control of long-term persistence of various microbes in the cells of the system of mononuclear phagocytes.
