ABSTRACT
No disponible
Subject(s)
Humans , Male , Adult , Chest Pain/etiology , Elastic Tissue/physiopathology , Aortic Aneurysm, Thoracic/diagnosis , Tomography, X-Ray ComputedSubject(s)
Aortic Aneurysm, Thoracic/diagnosis , Aortic Dissection/diagnosis , Chest Pain/etiology , Marfan Syndrome/diagnosis , Adult , Aortic Dissection/complications , Aortic Dissection/genetics , Aortic Dissection/surgery , Aortic Aneurysm, Thoracic/complications , Aortic Aneurysm, Thoracic/genetics , Aortic Aneurysm, Thoracic/surgery , Ectopia Lentis/genetics , Electrocardiography , Fatal Outcome , Hemothorax/etiology , Humans , Intellectual Disability/complications , Male , Marfan Syndrome/complications , Pleural Effusion/etiology , Syndrome , Tachycardia/etiology , Tunica Intima/pathology , Wolff-Parkinson-White Syndrome/complications , Wolff-Parkinson-White Syndrome/surgeryABSTRACT
No disponible
No disponible
Subject(s)
Humans , Osteoporosis/diagnosis , Densitometry , Fractures, Bone/prevention & control , Risk Factors , Practice Patterns, Physicians'ABSTRACT
BACKGROUND & AIMS: Progress in the understanding of susceptibility factors to drug-induced liver injury (DILI) and outcome predictability are hampered by the lack of systematic programs to detect bona fide cases. METHODS: A cooperative network was created in 1994 in Spain to identify all suspicions of DILI following a prospective structured report form. The liver damage was characterized according to hepatocellular, cholestatic, and mixed laboratory criteria and to histologic criteria when available. Further evaluation of causality assessment was centrally performed. RESULTS: Since April 1994 to August 2004, 461 out of 570 submitted cases, involving 505 drugs, were deemed to be related to DILI. The antiinfective group of drugs was the more frequently incriminated, amoxicillin-clavulanate accounting for the 12.8% of the whole series. The hepatocellular pattern of damage was the most common (58%), was inversely correlated with age (P < .0001), and had the worst outcome (Cox regression, P < .034). Indeed, the incidence of liver transplantation and death in this group was 11.7% if patients had jaundice at presentation, whereas the corresponding figure was 3.8% in nonjaundiced patients (P < .04). Factors associated with the development of fulminant hepatic failure were female sex (OR = 25; 95% CI: 4.1-151; P < .0001), hepatocellular damage (OR = 7.9; 95% CI: 1.6-37; P < .009), and higher baseline plasma bilirubin value (OR = 1.15; 95% CI: 1.09-1.22; P < .0001). CONCLUSIONS: Patients with drug-induced hepatocellular jaundice have 11.7% chance of progressing to death or transplantation. Amoxicillin-clavulanate stands out as the most common drug related to DILI.
