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1.
Minerva Stomatol ; 51(5): 187-92, 2002 May.
Article in Italian | MEDLINE | ID: mdl-12070469

ABSTRACT

Biofilm is defined as a community of bacteria intimately associated with each other and included within an exopolymer matrix: this biological unit exhibits its own properties, quite different in comparison with those showed by the single species in planktonic form. The oral cavity appears as an open ecosystem, with a dynamic balance between the entrance of microrganisms, colonisation modalities and host defences aimed to their removal: to avoid elimination, bacteria need to adhere to either hard dental surfaces or epithelial surfaces. The oral biofilm formation and development, and the inside selection of specific microrganisms have been correlated with the most common oral pathologies, such as dental caries, periodontal disease and peri-implantitis. Many of these bacteria are usual saprophytes of the oral environment, that, in particular situations, can overcome and express their virulence factors: to better understand the mechanisms of these pathologies it's necessary to know the complex interactions between all the bacterial species inside the biofilm and host tissues and responses. The present paper is a review of the most significant studies on the biofilm development modalities, their correlations with either health or illness of the oral cavity, the bacterial co-aggregation strategies and the biofilm response to antimicrobial agents.


Subject(s)
Biofilms , Dental Plaque/microbiology , Mouth/microbiology , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/therapeutic use , Bacterial Adhesion , Bacterial Physiological Phenomena , Biofilms/drug effects , Biofilms/growth & development , Dental Caries/etiology , Dental Caries/microbiology , Humans , Periodontal Diseases/etiology , Periodontal Diseases/microbiology , Tooth/microbiology , Virulence
2.
Minerva Stomatol ; 51(3): 79-85, 2002 Mar.
Article in Italian | MEDLINE | ID: mdl-11887077

ABSTRACT

In the "Glossary of Periodontics Terms" written by the American Academy of Periodontology, the occlusal trauma is defined as "an injury to the attachment apparatus as a result of excessive occlusal forces". Nowadays, the effects of occlusal trauma on tooth support tissues, the onset and the progression of periodontal disease are still debated: many commonplaces have been disproved, but some doubts and not yet clear points remain, even owing to the difficult diagnosis of the presence and the real clinical impact of a traumatic occlusion. Then, ethical reasons prevent researchers from prospective clinical trials. At the beginning of the last century occlusal trauma has been supposed to be an etiologic factor of "alveolar pyorrhea", but several studies attending more strict scientific criteria failed to prove such correlation. On the basis of the bacterial genesis of periodontal disease, researchers started evaluating the possible effects of occlusal discrepancies on incidence, progression and treatment outcomes of periodontitis, but all the results underlined the more relevant role played by micro-organisms. The present review of the literature runs through this controversy again, analysing the most significant studies published.


Subject(s)
Dental Occlusion, Traumatic/complications , Periodontal Diseases/etiology , Dental Occlusion, Traumatic/diagnosis , Humans
3.
Minerva Stomatol ; 49(10): 485-500, 2000 Oct.
Article in Italian | MEDLINE | ID: mdl-11268937

ABSTRACT

Strong relationships have been very often described between various form of periodontal disease (PD) and certain bacterial species, so that nowadays periodontal disease is recognized as an infectious disease. Destruction of periodontal supporting tissues happens as a response to very intricate host-parasite interactions. When the clinician will be able to fully understand and identify such phenomena it would be possible to succeed in a properly diagnosis and control of the active phase of periodontal disease. The first step in such a direction would be to analyze the common characteristic of some bacterial species, the so called suspected periodontopathogens. Such species namely Gram-negative, associated with the outbreak of periodontal disease have in common the capacity to disrupt the integrity of the host defences by means of the so called virulence factors. These factors may enhance the bacterial colonization or may interfere with the host response that ultimately results in periodontal support breakdown. The present review focuses on the virulence factors of the main suspected periodontopathogens evaluating the effects on the host immune response and directly on the periodontal tissues.


Subject(s)
Bacteria/pathogenicity , Bacterial Infections/complications , Periodontal Diseases/microbiology , Aggregatibacter actinomycetemcomitans/pathogenicity , Bacteroides/pathogenicity , Campylobacter/pathogenicity , Capnocytophaga/pathogenicity , Eikenella corrodens/pathogenicity , Fusobacterium nucleatum/pathogenicity , Humans , Porphyromonas gingivalis/pathogenicity , Prevotella intermedia/pathogenicity , Virulence
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