ABSTRACT
Estudo sobre o panorama epidemiológico das hepatites virais no Rio Grande do Sul. (AU)
Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Hepatitis C/epidemiology , Hepatitis A/epidemiology , Hepatitis B/epidemiology , IncidenceABSTRACT
Estudo do perfil epidemiológico da hepatite C no Rio Grande do Sul no período de 2013 a 2014. (AU)
Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Health Profile , Hepatitis C/transmission , Hepatitis C/epidemiology , Disease NotificationABSTRACT
Estudo sobre o perfil epidemiológico da hepatite B no Rio Grande do Sul no período de 2007 a 2014. (AU)
Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Health Profile , Hepatitis B/transmission , Hepatitis B/epidemiology , Disease NotificationABSTRACT
Estudo sobre o perfil epidemiológico da hepatite A no Rio Grande do Sul no período de 2007 a 2014. (AU)
Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Health Profile , Hepatitis A/epidemiology , Disease NotificationABSTRACT
S100B belongs to a family of calcium-binding proteins involved in cell cycle and cytoskeleton regulation. We observed an inhibitory effect of S100B on glial fibrillary acidic protein (GFAP) phosphorylation, when stimulated by cAMP or Ca2+/calmodulin, in a cytoskeletal fraction from primary astrocyte cultures. We found that S100B has no direct effect on CaM KII activity, the major kinase in this cytoskeletal fraction able to phosphorylate GFAP. The inhibition of GFAP phosphorylation is most likely due to the binding of S100B to the phosphorylation sites on this protein and blocking the access of these sites to the protein kinases. This inhibition was dependent on Ca2+. However, Zn2+ could substitute for Ca2+. The inhibitory effect of S100B was prevented by TRTK-12, a peptide that blocks S100B interaction with several target proteins including glial fibrillary acidic protein. These data suggest a role for S100B in the assembly of intermediate filaments in astrocytes.
