[Influence of antecedent of hypertension in patients with acute coronary syndrome without ST elevation]. / Influencia del antecedente de hipertensión arterial en los pacientes ingresados por síndrome coronario agudo sin elevación del segmento ST.

BACKGROUND AND OBJECTIVE: There are few studies evaluating the effect of a previous history of hypertension on long term prognosis after an acute coronary syndrome, using the new definitions and incorporating new risk markers in the analysis. The aim of our study was to determinate if hypertensive patients differ from non-hypertensives in the epidemiological profile, clinical presentation, treatment prescribed at discharge and prognosis after admission with non ST segment elevation acute coronary syndrome. PATIENTS AND METHOD: A total of 1,029 consecutive patients admitted with high suspicion of non ST segment elevation acute coronary syndrome were evaluated. Prognostic variables were determined during admission (epidemiological and biochemical), as it was the discharge treatment. The primary endpoint was defined as all cause mortality at one year follow up. RESULTS: 65.8% (n = 677) of patients had hypertension. Hypertensive patients displayed a worst epidemiological and biochemical profile, and different discharge treatment. There were 139 (13.5%) deaths at one year follow up. The all cause mortality for non-hypertensive patients was 12.5% and for hypertensives 14.6% (p = NS). In the multivariate analysis (Cox regression) there were no differences in mortality between these groups. CONCLUSIONS: A previous history of hypertension is an important factor to explain differences in the presence of other risk factors or the treatment, but is not a mortality predictor.

Influencia del antecedente de hipertensión arterial en los pacientes ingresados por síndrome coronario agudo sin elevación del segmento ST / Influence of antecedent of hypertension in patients with acute coronary syndrome without ST elevation

Fundamento y objetivo: Son pocos los estudios que evalúan el efecto del antecedente de hipertensión arterial en el pronóstico a medio-largo plazo tras un síndrome coronario utilizando las nuevas definiciones e incorporando los nuevos marcadores de riesgo en el análisis. El objetivo de nuestro estudio es determinar si hay diferencias entre los pacientes hipertensos y no hipertensos en cuanto al perfil epidemiológico, la forma de presentación, el tratamiento al alta y el pronóstico en los pacientes que ingresan en un hospital por un síndrome coronario agudo sin elevación del segmento ST. Pacientes y método: Se estudió a 1.029 pacientes consecutivos ingresados por síndrome coronario agudo sin elevación del segmento ST. Se determinaron las variables pronósticas durante el ingreso (epidemiológicas y bioquímicas), así como el tratamiento administrado al alta. Se siguió la evolución de los pacientes durante un año y el parámetro de valoración principal fue la mortalidad por todas las causas. Resultados: El 65,8% (n = 677) de los pacientes eran hipertensos. Estos pacientes presentaron un perfil epidemiológico y bioquímico más desfavorable, así como diferencias en cuanto al tratamiento al alta. Durante el primer año de seguimiento fallecieron 139 pacientes (13,5%). La mortalidad a un año fue del 12,5% en los no hipertensos y del 14,6% en los hipertensos (p = NS). En el análisis de regresión múltiple la hipertensión no mantuvo la significación estadística para la mortalidad. Conclusiones: El antecedente de hipertensión arterial es un factor importante en el desarrollo de un síndrome coronario agudo sin elevación del ST, ya que explica diferencias en cuanto a la presencia de otros factores de riesgo o al tratamiento, pero no se comporta como factor predictor de mortalidad

Background and objective: There are few studies evaluating the effect of a previous history of hypertension on long term prognosis after an acute coronary syndrome, using the new definitions and incorporating new risk markers in the analysis. The aim of our study was to determinate if hypertensive patients differ from non-hypertensives in the epidemiological profile, clinical presentation, treatment prescribed at discharge and prognosis after admission with non ST segment elevation acute coronary syndrome. Patients and method: A total of 1,029 consecutive patients admitted with high suspiction of non ST segment elevation acute coronary syndrome were evaluated. Prognostic variables were determined during admission (epidemiological and biochemical), as it was the discharge treatment. The primary endpoint was defined as all cause mortality at one year follow up. Results: 65.8% (n = 677) of patients had hypertension. Hypertensive patients displayed a worst epidemiological and biochemical profile, and different discharge treatment. There were 139 (13.5%) deaths at one year follow up. The all cause mortality for non-hypertensive patients was 12.5% and for hypertensives 14.6% (p = NS). In the multivariate analysis (Cox regression) there were no differences in mortality between these groups. Conclusions: A previous history of hypertension is an important factor to explain differences in the presence of other risk factors or the treatment, but is not a mortality predictor