ABSTRACT
Hepatitis G virus (HGV) is a parenterally transmitted virus, frequently associated with hepatitis C virus infection. Hepatitis G virus RNA was detected by reverse transcription-polymerase chain reaction in the serum of 40 patients with chronic hepatitis C. Nine (22.5%) patients had evidence of hepatitis G virus viraemia. No significant epidemiological or virological differences could be demonstrated between subjects infected with both hepatitis G virus and hepatitis C virus and subjects infected with hepatitis C virus alone. Aminotransferase values were comparable between the two groups, whereas higher levels of cholestatic enzymes (P< 0.001) were reported in the hepatitis G virus/hepatitis C virus-positive patients. A liver biopsy was performed on all 40 patients no later than 6 months before recruitment. The mean histological activity index did not differ between hepatitis G virus-positive and hepatitis G virus-negative patients, whereas specific histological features such as macrovesicular steatosis, portal granulomas, and bile duct damage were more commonly observed among the coinfected patients. The results indicate that coinfection with hepatitis G virus probably does not have a significant effect on hepatitis C virus-induced hepatic damage.
Subject(s)
Flaviviridae , Hepatitis C, Chronic/complications , Hepatitis, Viral, Human/complications , Adult , Disease Progression , Female , Flaviviridae/genetics , Hepatitis C/genetics , Hepatitis C/immunology , Hepatitis C, Chronic/physiopathology , Hepatitis, Viral, Human/physiopathology , Humans , Male , RNA, Viral/blood , Reverse Transcriptase Polymerase Chain Reaction , ViremiaABSTRACT
The prevalence of hepatitis G in a multitransfused population was studied. HGV did not appear to be a major contributor to liver pathology in this group and the prevalence was surprisingly low.
Subject(s)
Flaviviridae/isolation & purification , Hepatitis, Viral, Human/complications , Hepatitis, Viral, Human/epidemiology , RNA, Viral/blood , Transfusion Reaction , beta-Thalassemia/complications , Adolescent , Adult , Female , Flaviviridae/genetics , Hepatitis, Viral, Human/transmission , Humans , Male , Polymerase Chain Reaction , Prevalence , RNA-Directed DNA Polymerase , Sicily/epidemiologyABSTRACT
Here we report a rare case of septic spondilodiskitis by methicillin-resistant Staphylococcus aureus, complicated by the atypical involvement of two articular sites such as manubrio-clavicular joints and right wrist. The source of the septic process was identified in hand's eczematous lesions and paronychia. A first therapeutical attempt performed by combining teicoplanin with netilmicin or rifampicin was useless. A new course with vancomycin instead of teicoplanin favoured the prompt remission of symptoms. Following 10 weeks of continuous treatment, we observed the complete disappearance of all radiological signs of vertebral damage. Though rarely, polyarthritis may complicate a Staphylococcus aureus bacteraemia. An adequate chemio-antibiotic course may lead to definitive recovery and avoid surgery.
