1.
Nucleic Acids Symp Ser (Oxf)
; (52): 595-6, 2008.
Article
in English
| MEDLINE
| ID: mdl-18776520
ABSTRACT
Three 7-fluoro-7-deaza-2-aminopurine nucleoside derivatives were synthesized and evaluated as potential inhibitors of RNA virus replication, including hepatitis C virus (HCV).
Subject(s)
Antiviral Agents/chemical synthesis , Purine Nucleosides/chemical synthesis , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , Hepacivirus/drug effects , Purine Nucleosides/chemistry , Purine Nucleosides/pharmacology
2.
Nucleic Acids Symp Ser (Oxf)
; (52): 603-4, 2008.
Article
in English
| MEDLINE
| ID: mdl-18776524
ABSTRACT
9-Deazaguanosine and the alpha and beta anomers of its 2'-C-methyl counter part, have been synthesized and evaluated against a broad range of RNA viruses, including hepatitis C virus.
Subject(s)
Antiviral Agents/chemical synthesis , Guanosine/analogs & derivatives , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , Flavivirus/drug effects , Guanosine/chemical synthesis , Guanosine/chemistry , Guanosine/pharmacology , Hepacivirus/drug effects , Virus Replication/drug effects
3.
Nucleic Acids Symp Ser (Oxf)
; (52): 611-2, 2008.
Article
in English
| MEDLINE
| ID: mdl-18776528
ABSTRACT
The first example of a nucleoside analogue bearing a 5'-deoxy-beta-D-allo-septanose as the sugar moiety was synthesized and evaluated as a potential inhibitor of several virus replication.
Subject(s)
Adenosine/analogs & derivatives , Antiviral Agents/chemical synthesis , Adenosine/chemical synthesis , Adenosine/chemistry , Adenosine/pharmacology , Antiviral Agents/chemistry , Antiviral Agents/pharmacology
4.
Nucleic Acids Symp Ser (Oxf)
; (52): 617-8, 2008.
Article
in English
| MEDLINE
| ID: mdl-18776531
ABSTRACT
A series of novel 4-fluoro-1H-pyrazole-3-carboxamide nucleoside analogues were synthesized and evaluated as potential inhibitors of RNA virus replication, including hepatitis C virus (HCV).
