ABSTRACT
Studies of intestinal absorptive functions in 11 hyperthyroid and 14 hypothyroid patients showed that steatorrhoea was common in hyperthyroid patients and rare in hypothyroid patients. D-xylose malabsorption was present in both the groups of thyroid disorders being more common in hypothyroid one. Occasionally vitamin B12 malabsorption was found in 2 hypothyroid patients. Jejunal mucosal changes were almost unremarkable. Both fat and carbohydrate malabsorption in both groups of patients appeared to be casually related to the thyroid dysfunction.
Subject(s)
Hyperthyroidism/complications , Hypothyroidism/complications , Malabsorption Syndromes/etiology , Adult , Celiac Disease/etiology , Celiac Disease/physiopathology , Female , Humans , Intestinal Absorption , Malabsorption Syndromes/physiopathology , Male , Middle AgedABSTRACT
Thirteen patients of duodenal ulcer, below 20 years of age, ten age and sex matched controls and 17 first probands were studied to find out (i) the special characteristics of this duodenal ulcer subtype and (ii) the serum alpha-1-antitrypsin (alpha-1-AT) activity in these patients and their first probands. Basal and maximal acid output, and serum level of alpha-1-AT were measured, and serum agar gel electrophoresis done, in the above subjects. Special characteristics like positive family history, and high basal (p less than or equal to 0.01) and maximal (p less than or equal to 0.001) acid output were noted in these patients. Serum alpha-1-AT was found to be deficient in nine patients. Five first probands also had the heterozygous level of the enzyme deficiency. Thus, patients of early onset duodenal ulcer seem to have special characteristics with alpha-1-antitrypsin deficiency in them as well as in their first probands.
Subject(s)
Duodenal Ulcer/genetics , alpha 1-Antitrypsin Deficiency , Adolescent , Adult , Child , Duodenal Ulcer/blood , Duodenal Ulcer/diagnosis , Female , Gastric Acidity Determination , Genetic Carrier Screening , Humans , Male , alpha 1-Antitrypsin/geneticsABSTRACT
Intestinal tuberculosis is still common in developing countries. In 186 patients with intestinal tuberculosis, clinical features, radiological findings and complications were carefully recorded and compared with those from earlier studies with a view to study any possible changes after the liberal use of antitubercular drugs. Sixty two percent of the patients in the present series had had prior exposure to antitubercular drugs. The incidence of systemic symptoms like fever and anorexia, alternating diarrhoea and constipation, peritoneal and lymph node involvements and associated pulmonary lesions were less frequently observed. On the other hand, an indolent and complicated course with intestinal obstruction (47%) and lower gastrointestinal bleeding (5.5%) and frequent colonic involvement (19%) often necessitating surgical intervention appeared to have become more frequent than reported in earlier series. Awareness of these changes in the clinical profile of intestinal tuberculosis should be helpful in the diagnosis and management of the condition.
Subject(s)
Intestinal Diseases/diagnosis , Tuberculosis, Gastrointestinal/diagnosis , Adult , Age Factors , Female , Humans , Intestinal Diseases/diagnostic imaging , Intestines/diagnostic imaging , Male , Middle Aged , Radiography , Sex Factors , Tuberculosis, Gastrointestinal/diagnostic imagingSubject(s)
Ascites/diagnosis , Laparoscopy , Adolescent , Adult , Aged , Ascites/etiology , Child , Female , Humans , Male , Middle Aged , Peritonitis, Tuberculous/complications , Peritonitis, Tuberculous/diagnosisSubject(s)
Abdomen , Tuberculosis , Abdomen/pathology , Adult , Female , Humans , Male , Tuberculosis/diagnosis , Tuberculosis/pathology , Tuberculosis/therapyABSTRACT
Bridging necrosis was recorded in 14% of 361 patients with acute viral hepatitis on examination of the liver biopsy. The clinical and biochemical features of acute viral hepatitis with bridging necrosis were compared with acute viral hepatitis with no bridging necrosis (NBN). It was noted that fever of more than 8 days' duration in the preicteric phase, the presence of mild ascites and pedal edema during the icteric phase, increasing or persistently high levels of serum bilirubin even 4 weeks after the onset of the icteric phase and positive hepatitis-B surface antigen were significantly more common in acute viral hepatitis with bridging necrosis. Hepatitis-B surface antigen clearance was slow in this group. The long-term complication of chronic hepatitis was more frequent in patients with acute viral hepatitis with bridging necrosis.
