[Organ-sparing treatment of prostate stromal tumor of uncertain malignancy potential].

A case of organ-preserving treatment of prostate stromal tumor with an uncertain malignancy potential is presented in the article. The patient underwent laparoscopic resection of the prostate neoplasm. Mesenchymal prostate tumors are rare. Their diagnosis is difficult due to the lack of experience of both pathologists and urologists. Mesenchymal neoplasms include prostate stromal tumors of uncertain malignant potential. Due to the rare occurrence of these tumors and the difficulties of its diagnosis, there is no recommended treatment algorithm. Taking into account the anatomical location of the tumor, the patient underwent enucleoresection without removing the entire prostate. The control examination, including pelvic MRI, was carried out after 3 months. There were no signs of disease progression. The presented clinical case of prostate preservation during resection of a prostate stromal tumor of uncertain malignancy potential demonstrates a possibility of organ-preserving procedures in such a rare disease. However, due to a small number of publications and a short follow-up period, these tumors require further study and evaluation of long-term results.

[The study of mineral composition and structure of uroliths in the residents of Tomsk district (Tomsk)].

AIM: To successfully treat and prevent urolithiasis, the composition and structure of uroliths should be examined using modern analytical techniques. For a long time, studies of the biomineral formation in the human body have been conducted exclusively in the field of medicine. The main attention has been paid to the diagnosis and treatment of diseases leading to the occurrence of pathogenic formations. At the same time, it is quite obvious that it is important to have a clear idea about the causes of pathogenic formations, the mechanisms for their further formation, composition and structure. Currently, these issues are widely studied all over the world by mineralogists, biochemists, geo-ecologists using methods of mineralogical analysis. The aim of this work was to determine the content of the elements that make up uroliths. This value should be normalized by the clarks of the noosphere. Studies on the mineral composition and structure of uroliths in the Tomsk region allowed to calculate the content of elements. It turned out that each medical district has its own specific geochemical series, which depends, probably, on natural and technogenic factors. MATERIALS AND METHODS: The study included urolith samples obtained from residents of 4 medical sub-districts of Tomsk district. 100 samples of different mineral composition were studied. Analytical techniques including crystal-morphological, spectral, X-ray structural, instrumental neutron-activation, electron microscopic analyses were used to investigate the morphology, mineral composition and structure of uroliths. RESULTS: The average content of elements in the uroliths, and the element concentrations normalized by the clark were established. After calculating the concentration, geochemical associative series of elements were formed. Depending on the morphology, drusiform, microspherolite, porous, coral formations, uroliths with a smoothed surface and stones with combined morphology were identified. Three groups of uroliths were defined according to their structural features: crystalline-granular, spherolithic and combined. CONCLUSION: Studies to determine the mineral composition and structure of the uroliths of the inhabitants of the Tomsk region made it possible to calculate the content of the elements that make up uroliths, normalized by clarks of the noosphere. Each medical sub-district has its own specific geochemical series, which depends on natural and technogenic factors. The increased value of the indicator of the content of elements in uroliths should serve as a warning factor for developing measures to reduce the urolithiasis incidence in the population.

[The list of literature (review) on studying urinary stones by russian researchers (Dated between 1965 and 2015, in 2 parts) Part I].

Urolithiasis is one of the most common urological diseases. Determination of mineral composition and structure of urinary stones is necessary for urologists to provide targeted therapeutic and preventive measures. Existing global standards for management of kidney stones require analysis of stone composition to be done for each urolithiasis patient. The list of literature representing the scientific work of the Russian scientists on studying the mineral composition and structure of urinary stones, includes articles, abstracts, monographs, dissertations presented as reports and presentations at conferences and seminars (mineralogical and urological). Over half a century (1965-2015) there were 178 articles published in geological and urological journals, 7 published monographs and 8 defended dissertations (2 on Medical Sciences and 6 on Geological and Mineralogical Sciences).

[The list of literature (review) on studying urinary stones by russian researchers (Dated between 1965 and 2015, in 2 parts) Part II].

Research on urinary stones involves urologists, crystallographers, mineralogists. A considerable amount of literature has been published as articles, abstracts of articles presented at conferences and seminars (mineralogical and urological), and monographs, dissertations. The authors of the scientific review prepared the list of the literature, reflecting the scientific activities of Russian scientists in studying the mineral composition and structure of urinary stones for half a century (1965-2015). The list is presented in two parts. The information provided in the 2nd part (2002-2015), is an update of the scientific review on studying urinary stones (Part I, 1965-2001).

[A contact electroimpulse impact on the ureteral and bladder wall of mature dogs: a 1-year results of a morphological prospective study].

The aim of the study was investigation of morphological changes in the urinary bladder and ureteral wall of dogs in response to contact electroimpulse impact (CEII); to develop recommendations for utilization of contact electroimpulse lithotripsy in humans. Effects of single-impulse CEII on the bladder and ureteral mucosa produced by an electroimpulse lithotripter were studied in 23 mature mongrel dogs. The morphological material was studied immediately after the impact, 1, 6, 14 days and 1, 3, 6 and 12 months after it. The 0.1-0.7 J electroimpulse impact resulted in fragmentary epithelial necrosis and aceptic inflammation within a muscular layer. An enhanced to 0.8 J impact caused local damage to all layers of the wall including adventitium while a 0.9-1 J impact caused ureteral perforation in 3 cases. Duration of morphological rehabilitation depended on the impact power and was optimal for 0.1-0.5 J impulses with complete mucosal repair to day 14 and complete morphological rehabilitation to month 6 after the procedure. In power 0.6-1 J mucosal recovery increased to 1 month while complete formation of the connective tissue finished after 1 year. None cases of development of ureteral strictures after CEII was observed in follow-up for 1 year.

[Contact electroimpulse lithotripsy].

Efficacy and safety of endoscopic contact electroimpulse lithotripsy (EILT) were studied in 146 patients with urolithiasis (mean age 48+/-16 years). Of them, 10 (7%) had ureteropelvic (UP) concrements, 124 (85%) had ureteroliths and 12 (8%) had bladder stones. The impulses were generated by the electroimpulse lithotripter Urolit-105M (Lithotech Medical, Israel; MedLine, Russia). EILT produced a complete destruction of UP concrements, ureteroliths and bladder stones in 96% cases. Complications occurred in 8.2% cases. The risk of intraoperative EILT complications was higher in destruction of stones more than 8 mm in the largest parameter of size, long-standing ureteral concrements complicated by ureteritis. EILT of UP concrements must be conducted by means of single impulses (impulse energy 0.45 J), of ureteroliths--by single or paired impulses (impulse energy 0.45-0.6 J), of bladder stones--by paired or serial impulses (impulse energy 0.6-0.7 J).

[Fractionated low-intensity thermotherapy of benign prostatic hyperplasia]. / Drobnaia nizkointensivnaia termoterapii dobrokachestvennoi giperplazii predstatel'noi zhelezy.

120 patients with benign prostatic hyperplasia (BPH) (mean age 65.8 +/- 7.7 years) received fractional low-intensity transurethral microwave thermotherapy (FLITMT). Each patient was exposed to 4 FLITMT procedures with 3-4 day interval (duration--60 min at 48.5-49.9 degrees C, ProsTek 3000 unit, USA). Subjective and objective effects of FLITMT were observed in 87 (82.9%) and 75 (71.4%) patients, respectively. A stable effect on IPSS persisted for 3 years, on acceleration of maximal urination rate--within a year. Moreover, FLITMT was associated with a low frequency of complications. This makes the above thermotherapy usable in all BPH patients without absolute indications for surgical treatment.