Subject(s)
COVID-19 , Chickenpox , Herpes Simplex , Herpes Zoster , COVID-19 Vaccines , Erythema/chemically induced , Humans , SARS-CoV-2 , Vaccination/adverse effectsABSTRACT
BACKGROUND: Cutaneous reactions may occur in patients receiving terbinafine therapy, mainly rash and urticaria. More exceptionally, development of psoriasis has been described. We describe the development of plantar pustular psoriasis in a patient who took oral terbinafine. CASE REPORT: A 70-year-old man, without previously known history of psoriasis, was treated with terbinafine, 250 mg/day, for onychomycosis. Ten days later, a plantar pustular psoriasis appeared. The psoriasis cleared up after discontinuation of terbinafine and institution of antipsoriatic therapy. DISCUSSION: Terbinafine is an antifungal agent widely use in the treatment of onychomycosis. A skin reaction occurs in 3 p. 100 of patients. Only 24 cases of flare-up of previous psoriasis or psoriasis de novo after terbinafine have been described. The psoriasis generally clears after discontinuation of terbinafine. So, terbinafine is perhaps not the best first line therapy for onychomycosis in patients with psoriasis.
Subject(s)
Antifungal Agents/adverse effects , Drug Eruptions/diagnosis , Foot Dermatoses/chemically induced , Naphthalenes/adverse effects , Psoriasis/chemically induced , Administration, Oral , Aged , Antifungal Agents/therapeutic use , Biopsy , Drug Eruptions/pathology , Foot Dermatoses/diagnosis , Foot Dermatoses/pathology , Humans , Male , Naphthalenes/therapeutic use , Onychomycosis/drug therapy , Psoriasis/diagnosis , Psoriasis/pathology , Skin/pathology , TerbinafineSubject(s)
Ear Diseases/diagnosis , Ear, External , Eyelid Diseases/diagnosis , Skin Diseases, Papulosquamous/diagnosis , Ear Diseases/surgery , Ear, External/surgery , Eyelid Diseases/surgery , Humans , Male , Middle Aged , Recurrence , Reoperation , Skin Diseases, Papulosquamous/surgery , Surgery, PlasticABSTRACT
BACKGROUND: Acute generalized exanthematic pustulosis is a severe adverse drug reaction which occurs after taking antibiotics. Rare cases implicating psychotrops have been observed. CASE REPORT: A 71-year old women with schizophrenia was given closapine for six weeks when she developed an erythematopustular skin reaction and fever typical of acute generalized exanthematic pustulosis. The skin disease regressed one week after withdrawing clozapine. DISCUSSION: This is the first case of acute generalized exanthematic pustulosis observed after taking the neuroleptic drug, clozapine, used in severe schizophrenia.