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Vasa ; 37(4): 374-8, 2008 Nov.
Article in English | MEDLINE | ID: mdl-19003750

ABSTRACT

Accidental intra-arterial injection of drugs is a sporadic complication in i.v. drug addicts. A 22-year-old drug-abuser injected flunitrazepam tablets dissolved in tap water into her left femoral artery and presented with clinical signs of acute ischaemia of the left leg. Severe rhabdomyolysis developed within 5 hours after the injection. Selective arterial catheter angiography showed an acute occlusion of the posterior tibial artery. Combination therapy with i.a. urokinase, i.a. prostaglandines and i.v. anticoagulation resulted in re-opening of the obstructed distal artery and complete cessation of symptoms.


Subject(s)
Arterial Occlusive Diseases/chemically induced , Flunitrazepam/adverse effects , GABA Modulators/adverse effects , Ischemia/chemically induced , Leg/blood supply , Substance Abuse, Intravenous/complications , Tibial Arteries/drug effects , Acute Disease , Anticoagulants/therapeutic use , Arterial Occlusive Diseases/drug therapy , Arterial Occlusive Diseases/pathology , Drug Therapy, Combination , Female , Femoral Artery , Fibrinolytic Agents/therapeutic use , Flunitrazepam/administration & dosage , GABA Modulators/administration & dosage , Humans , Injections, Intra-Arterial , Ischemia/drug therapy , Ischemia/pathology , Prostaglandins/therapeutic use , Radiography , Rhabdomyolysis/chemically induced , Solubility , Tablets , Tibial Arteries/diagnostic imaging , Treatment Outcome , Young Adult
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