1.
Appl Radiat Isot
; 64(2): 182-6, 2006 Feb.
Article
in English
| MEDLINE
| ID: mdl-16169239
ABSTRACT
An improved synthesis of the precursor acetic acid-piperidine-4-yl ester by acetylation of 4-hydroxypiperidine hydrochloride in anhydrous chloroform was developed. A procedure for fast evaluation and characterization of products originated by acetylation of the 4-piperidinol using LC-APCI/MS with an acetonitrile-water gradient method on a Merck Purosphere RP-18 column was also developed. The highly purified precursor allowed the production of [11C]MP4A for PET studies of acetylcholine neurotransmission system. The tracer was produced with >98% radiochemical purity, with yields ranging 20-60% (decay-corrected) from EOB.
Subject(s)
Acetates/chemical synthesis , Hydrocarbons, Iodinated/chemistry , Piperidines/chemical synthesis , Radiopharmaceuticals/chemical synthesis , Acetates/chemistry , Acetylation , Acetylcholinesterase/analysis , Chromatography, High Pressure Liquid , Gas Chromatography-Mass Spectrometry , Humans , Isotope Labeling/methods , Magnetic Resonance Spectroscopy , Piperidines/chemistry , Positron-Emission Tomography/methods , Radiopharmaceuticals/chemistry
2.
Thesis
in French
| AIM (Africa)
| ID: biblio-1277067