1.
Psychiatry Res
; 45(4): 227-37, 1992 Dec.
Article
in English
| MEDLINE
| ID: mdl-1292040
ABSTRACT
Changes of serotonin2 (5HT2) receptors have been described in depression, and long-term antidepressant treatment has been shown to decrease the number of 5HT2 receptors. In this study, single photon emission computed tomography (SPECT), with 2-123I-ketanserin as a ligand, was used to investigate 5HT2 receptors in vivo in the brain of depressed patients and normal volunteers. A higher uptake of the tracer was observed in the parietal cortex of the patients, and there was a right greater than left asymmetry in the infero-frontal region of the depressed subjects and not in that of the control subjects. These findings could indicate changes in 5HT2 receptors in major depression.
Subject(s)
Brain/diagnostic imaging , Depressive Disorder/diagnostic imaging , Receptors, Serotonin/physiology , Tomography, Emission-Computed, Single-Photon , Adolescent , Adult , Aged , Brain/physiopathology , Brain Mapping , Cerebral Cortex/diagnostic imaging , Cerebral Cortex/physiopathology , Depressive Disorder/physiopathology , Dominance, Cerebral/physiology , Female , Humans , Ketanserin/pharmacokinetics , Male , Middle Aged , Parietal Lobe/diagnostic imaging , Parietal Lobe/physiopathology
2.
Int J Nucl Med Biol
; 5(2-3): 144-7, 1978.
Article
in English
| MEDLINE
| ID: mdl-110713