[The extension of retinoblastoma into neighboring structures]. / Extinderea retinoblastomului la structurile vecine.

Fourteen cases with retinoblastoma has been histologic studied. In eleven cases of them has been observed the invasion in the neighbour structures following the tumoral mass development: four cases in the vitreous, one case in the vitreous and the choroid, sclera and the optic nerve, one case in the vitreous choroid and optic nerve, two cases in the optic nerve. The tumoral invasion in the neighbour structures was observed only at the undifferentiated retinoblastoma.

[Genetic studies in retinoblastoma]. / Cercetari genetice în retinoblastom.

For a fifteen year period it has been hospitalized in Ophthalmologic Clinic from Craiova nineteen cases with retinoblastoma, seventeenth of them have been sporadic forms and two hereditary forms. It was found chromosomal changes at the two hereditary forms, consisting by a deletion of the long arm of chromosome 13.

Microscopic and ultrastructural aspects in retinoblastoma.

A number of 12 retinoblastoma cases were studied. We had in view a number of histopathological aspects (tumor type, neighbouring structures invasion) which are considered to be decisive in appreciating the vital prognosis. We mention that undifferential retinoblastoma of histopathological type was met in 8 cases and the neighbouring structures invasion was present in 7 of them. We also studied the ultrastructura of the tumor cells belonging to the malignant tumor.

[Ultramicroscopic studies in retinoblastoma]. / Cercetari ultramicroscopice în retinoblastom.

Were examined three cases with undifferentiated retinoblastoma. Were effected cross sections on the samples, remarking tumoral cells with normal aspect interspersed with tumoral necrosis cells. Tumoral cells of the undifferentiated retinoblastoma has low size and a poor cytoplasmic with a big nucleus that occupies nearly the whole cell; the ratio nucleus/cytoplasmic is increased. The cells are uni- or binucleus and the nucleus is monstrous deep invagination of the cover nucleus. Cytoplasmic has poor organelles and mitochondria are swelling following a high degree of hypoxia. Also tumoral cells on remark nontumoral cells (melanocyte).

[Anatomicopathological studies in retinoblastoma]. / Cercetari anatomopatologice în retinoblastom.

For a fifteen-years period it has been examined fourteen cases with retinoblastoma, twelve of them have been undifferentiated forms and two cases differentiated forms in rosette, in undifferentiated retinoblastoma has been observed low size cells with poor cytoplasm and big nucleus that occupied near the whole cell; the nucleus to cytoplasm ratio is increased. The cellular density is irregular and most important perivascular. The tumoral parenchyma is condensed in perivascular areas, the tumoral stroma is poor, amorphous or mucinous. The necrosis areas are frequently but very import out in undifferentiated retinoblastoma. The tumoral vascularity is increased. In some cases occur melanin pigment that belong to the pigment epithelium without the existence of tumoral proliferation.

[Clinical and statistical study in retinoblastoma]. / Aspecte clinico-statistice în retinoblastom.

Between 1982-1996 nineteen cases with retinoblastoma were hospitalized. Thirteen of them were one to three years old. The study of their origin shows fourteen cases by rural medium and five cases by city medium, seventeen cases had an unilateral evolution and two cases a bilateral evolution. Clinical manifestations which requested ophthalmological exam were: secondary glaucoma in twelve cases, leukochoria in ten cases, decreased of visual acuity in eight cases, inflammation of uvea in three cases, strabismus in two cases, buphthalmia in one case. On insist belated (100 late) presentation by the physician. Computer tomography shows the area of tumour and its extension at the neighbour structures.

[Invasion of the optic nerve in undifferentiated retinoblastoma]. / Invadarea nervului optic în retinoblastomul nediferentiat.

The case of a 2- and a half-year-old child is presented. The diagnosis was left-eye retinoblastoma and the left-eye enucleation was done. The anatomic-pathological exam emphasizes a microscopic structure of undifferentiated retinoblastoma, with the invasion of the optic nerve. After about 11 months, the child came again, presenting a tumoral mass which occupies almost entirely the orbital cavity, and also an altered general status.

[Ocular manifestations in Peters' syndrome]. / Manifestari oculare în sindromul Peters.

The analysis of twenty-one observations with Peter Syndrome, shows that the disease was established by a disorder in the development of the mesoderm who gives birth at the posterior, stratum of cornea, iris stroma and angle of the posterior chamber. The disease was associated with cataract (nine cases), strabismus (seven cases), congenital glaucoma (five cases), microophthalmia (three cases), microcornea (four cases), remainders of the pupillary membrane (one case), vitreous opacities (one case), facial malformations (one case), congenital dacryocystitis (one case), nystagmus (four cases). The presence at the same patient of the posterior keratoconus or staphiloma of cornea at one eye and Peter syndromme at the other eye, is possible to say that these diseases are evolutionary stages by one and the same mesodermal disgenesia.

[Persistence of the primordial vitreous body and buphthalmos]. / Persistance du corps vitré primitif et buphtalmie.

Persistence of the hyperplasic primordial vitreous body is determined by a deletion of embryonal development of the vitreous body and of the hyaloid vascular system. Infant aged 3.5 years presents persistence of primordial vitreous body with crystalline dislocation in the camera aquosa and secondary buphthalmos of the left eye and microphthalmos with dislocation of the crystalline in the vitreous body of the right eye. At the back of the right eye we noticed a whitish mass, richly vascularized with vestiges from the hyaloid artery, but the posterior half of the vitreous cavity is filled with microscopic blood; the fibrovascular membrane is made of conjunctive tissue set in parallel layers and vessels with macrolipophagic degeneration. Microscopic investigation of retina reveals glial hyperplasia zones in the neighbourhood of the vitreous body. In the present paper the authors show the persistence of the primordial vitreous body in the left eye and bilateral dislocation of the crystalline, revealing multiple ocular malformations.

[Tarsorrhaphy of necessity]. / Tarsorafia de necesitate.

From 1990 to 1994, 68 permanent and temporary tarsorrhaphies have been done: 39 in lagophthalmos, 7 in herpetic keratitis, 2 in zoster keratitis, 1 in neuroparalytic keratitis, 7 in corneal burns and 12 in corneal trophic ulceration with local and general metabolic disturbance. In 38 cases, permanent external tarsorrhaphies and in 60 cases temporary external tarsorrhaphies have been done. The postoperative results were good and the corneal lesion cure has been obtained in 4-19 days. The temporary tarsorrhaphy must be maintained for 2-6 months and has the role of biologic, trophic and tectonic bandage.

[Secondary glaucoma in the Weill-Marchesani syndrome]. / Glaucomul secudar în sindromul Weill-Marchesani.

The observation on a female patient with anterior underluxation of the lens at the right eye, secondary absolute glaucoma at the right eye, posterior luxation of the lens at the left eye, pathological cataract at both eyes. The general somatic exam shows low tallness, short members, brachydactyly and reduced functional mobility. The clinical manifestations point out a Weill-Marchesani syndrome . The underluxation of the lens determined secondary glaucoma in the absolute stage at the right eye, while the evolution of the lens luxation in vitreous at the left eye kept the visual function. The secondary glaucoma in the Weill-Marchesani syndrome is not a compulsory complication of it.