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Emergence of a pneumococcal clone with cephalosporin resistance and penicillin susceptibility.

Smith, A M; Botha, R F; Koornhof, H J; Klugman, K P.

Antimicrob Agents Chemother ; 45(9): 2648-50, 2001 Sep.

Article in English | MEDLINE | ID: mdl-11502545

ABSTRACT

We report two South African serotype 6B pneumococcal isolates with cephalosporin resistance, yet with susceptibility to penicillin. DNA fingerprinting revealed that they were clonal in origin. pbp 2X and 1A genes showed major alterations typical of cephalosporin-resistant pneumococci. The pbp 2B gene was completely unaltered, explaining the penicillin susceptibility of the isolates.

Subject(s)

Bacterial Proteins , Carrier Proteins/genetics , Cephalosporin Resistance/genetics , Hexosyltransferases/genetics , Multienzyme Complexes/genetics , Muramoylpentapeptide Carboxypeptidase , Penicillins/pharmacology , Peptidyl Transferases/genetics , Streptococcus pneumoniae/genetics , Amino Acid Sequence , Humans , Microbial Sensitivity Tests , Molecular Sequence Data , Penicillin-Binding Proteins , Sequence Homology, Amino Acid , South Africa , Streptococcus pneumoniae/drug effects

ABSTRACT

Subject(s)

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