ABSTRACT
In this research we present the results of the liver histopathological examinations after the administration of the Piroxicam (Pirox) and its complex combinations with metal bio-ions Cu (II), Co (II), Zn (II) to rats (White Wistar, 150-180 gr.). The results of the histological investigations are presented separately for each compound revealing the modifications after 24 hours and after 7 days. The hepatic lesions are noted in the case of Zn-Pirox after 24 hours and after 7 days, as well. The complexes Cu-Pirox and Co-Pirox don't produce hepatic modifications either after 24 hours or after 7 days according to our histological investigations.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Cobalt/adverse effects , Copper/adverse effects , Liver/drug effects , Liver/pathology , Piroxicam/adverse effects , Zinc/adverse effects , Animals , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Cobalt/administration & dosage , Copper/administration & dosage , Models, Animal , Necrosis/chemically induced , Piroxicam/administration & dosage , Rats , Rats, Wistar , Zinc/administration & dosageABSTRACT
The complex combinations of Piroxicam (Pirox) with the metallic bio-ions: Cu(II), Co(II), Zn(II) have been obtained and defined in a previous stage by physical-chemical methods (IR, X, SM, CSS-UV, DTA, DTG), an toxicological and biochemical aspect. In this research are presented the results of the histological examinations at the level of stomach, for each compound, at 24 hours and at 7 days after the administration of the Piroxicam and of its complexes to rats. The tissues histo-pathological investigation has pointed out lesions the glandular stomach level (necrosis, ulcers) especially after the administration of the Piroxicam and of the Zn-Pirox complex. Name of these have been present after the administration of Cu-Pirox, Co-Pirox.
