ABSTRACT
OBJECTIVE: To assess the impact of type 2 diabetes mellitus (T2DM) on prognosis of patients hospitalized because of acute decompensated heart failure (ADHF). MATERIALS AND METHODS: We analyzed data of the hospital register of ADHF which comprised information on 735 patients (254 [35%] with T2DM) consecutively admitted in 2010-2011. Median follow-up was 1790 days. RESULTS: The presence of T2DM was associated with increased risk of death: during the index hospitalization due to ADHF (hazard ratio [HR] 1.7, 95% confidence interval [CI] 1.0-2.8), within 18 months (HR 1.4, 95% CI 1.0-1.8), and within 5 years (HR 1.3, 95% CI 1.0-1.5). CONCLUSIONS: T2DM is common among acute decompensated heart failure patients (up to 35% of cases). T2DM is an independent risk factor of death during the index hospitalization and over the next 18 months and 5 years.
Subject(s)
Diabetes Mellitus, Type 2 , Heart Failure , Acute Disease , Hospitalization , Humans , PrognosisABSTRACT
OBJECTIVE: To assess the impact of type 2 diabetes mellitus (T2DM) on prognosis of patients hospitalized because of acute decompensated heart failure (ADHF). MATERIALS AND METHODS: We analyzed data of the hospital register of ADHF which comprised information on 735 patients (254 [35%] with T2DM) consecutively admitted in 2010-2011. Median followup was 1790 days. RESULTS: The presence of T2DM was associated with increased risk of death: during the index hospitalization due to ADHF (hazard ratio [HR] 1.7, 95% confidence interval [CI] 1.0-2.8), within 18 months (HR 1.4, 95% CI 1.0-1.8), and within 5 years (HR 1.3, 95% CI 1.0-1.5). CONCLUSIONS: T2DM is common among acute decompensated heart failure patients (up to 35% of cases). T2DM is an independent risk factor of death during the index hospitalization and over the next 18 months and 5 years.
Subject(s)
Diabetes Mellitus, Type 2 , Heart Failure , Acute Disease , Hospitalization , Humans , Prognosis , Proportional Hazards ModelsABSTRACT
Type 2 diabetes mellitus (DM) is often combined with chronic heart failure (CHF). Cardiovascular autonomic neuropathy (CAN) is widely spread complication of DM. In this work we studied effect of CAN on the course of CHF in patients with type 2 DM. We have shown unfavorable effect of CAN on the rate of development of myocardial infarction and course of CHF in patients with type 2 DM. We have demonstrated participation of CAN in pathogenesis of CHF and necessity of diagnostics of CAN in patients with combination of type 2 DM and CHF.
