ABSTRACT
De Ritis described the ratio between the serum levels of aspartate transaminase (AST) and alanine transaminase (ALT) almost 50 years ago. While initially described as a characteristic of acute viral hepatitis where ALT was usually higher than AST, other authors have subsequently found it useful in alcoholic hepatitis, where AST is usually higher than ALT. These interpretations are far too simplistic however as acute viral hepatitis can have AST greater than ALT, and this can be a sign of fulminant disease, while alcoholic hepatitis can have ALT greater than AST when several days have elapsed since alcohol exposure. The ratio therefore represents the time course and aggressiveness of disease that would be predicted from the relatively short half-life of AST (18 h) compared to ALT (36 h). In chronic viral illnesses such as chronic viral hepatitis and chronic alcoholism as well as non-alcoholic fatty liver disease, an elevated AST/ALT ratio is predictive of long terms complications including fibrosis and cirrhosis. There are methodological issues, particularly whether or not pyridoxal phosphate is used in the transaminase assays, and although this can have specific effects when patient samples are deficient in this vitamin, these method differences generally have mild effects on the usefulness of the assays or the ratio. Ideally laboratories should be using pyridoxal phosphate supplemented assays in alcoholic, elderly and cancer patients who may be pyridoxine deplete. Ideally all laboratories reporting abnormal ALT should also report AST and calculate the De Ritis ratio because it provides useful diagnostic and prognostic information.
ABSTRACT
BACKGROUND: Schneiderian first rank symptoms are included in the most influential operative diagnostic criteria, such as the ICD-10 and the DSM-IV. Many studies have examined their prevalence in the West, but their prevalence in non-Western countries still needs to be explored given that cultural beliefs are so different. AIMS: The aim of this study is to shed some light on Schneiderian first rank symptoms (FRS) as they occur in patients with schizophrenia in Egypt. METHOD: Forty-two patients were interviewed, their demographic characteristics studied and FRS elicited. The SPSS computer program was used to analyse the data. RESULTS: The prevalence rate of FRS was found to be 67%, which is similar to previous studies both in the East and the West. The study also showed that demographic variables had no significant relation to the prevalence of FRS except for nationality and social status. CONCLUSION: Schneiderian first rank symptoms transcend cultural barriers. However, strong cultural beliefs about the influence of supernatural forces on humans should nonetheless be carefully considered in eliciting delusions of control, influence or passivity.
