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Neoadjuvant sorafenib combined with gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma.

Williet, Nicolas; Dubreuil, Olivier; Boussaha, Tarek; Trouilloud, Isabelle; Landi, Bruno; Housset, Martin; Botti, Muriel; Rougier, Philippe; Belghiti, Jacques; Taieb, Julien.

World J Gastroenterol ; 17(17): 2255-8, 2011 May 07.

Article in English | MEDLINE | ID: mdl-21633538

ABSTRACT

This paper reports the first case of a patient with hepatocellular carcinoma with lymph node metastasis treated by sorafenib combined with gemcitabine plus oxaliplatin, with a partial response and normalization of α fetoprotein, which allowed curative surgery. The potential synergy between these three drugs needs to be confirmed, and is currently being investigated in a randomized phase II trial.

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Benzenesulfonates/therapeutic use , Carcinoma, Hepatocellular/drug therapy , Deoxycytidine/analogs & derivatives , Liver Neoplasms/drug therapy , Neoadjuvant Therapy , Organoplatinum Compounds/therapeutic use , Pyridines/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Benzenesulfonates/administration & dosage , Carcinoma, Hepatocellular/pathology , Deoxycytidine/administration & dosage , Deoxycytidine/therapeutic use , Humans , Liver Neoplasms/pathology , Male , Middle Aged , Niacinamide/analogs & derivatives , Organoplatinum Compounds/administration & dosage , Oxaliplatin , Phenylurea Compounds , Pyridines/administration & dosage , Sorafenib , Gemcitabine

ABSTRACT

Subject(s)

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