ABSTRACT
Fluorescence imaging is a versatile tool for biological and preclinical studies with steady improvements in performance thanks to instrumentation and probe developments. The sensitive detection and imaging of deep targets in vivo is especially challenging due to the diffusion and absorption of light by the tissues and to the emission of autofluorescence from intrinsic chromophores. Fluorescent inorganic nanoparticles present interesting optical properties that may significantly differ from organic dyes. In this short review, we present recent developments in the design of these nanoprobes and their use for new in vivo fluorescence modalities which provide enhanced imaging capabilities.
Subject(s)
Fluorescent Dyes/analysis , Nanotechnology , Animals , Fluorescent Dyes/chemistry , Humans , Multimodal Imaging , Nanoparticles/chemistry , Time FactorsABSTRACT
Cornea Plana is a bilateral and asymmetric congenital malformation of the corneo-scleral shape. Corneo-scleral lenses are said to be the preferential treatment. We reported the case of a 20-year-old woman, whose Cornea Plana was diagnosed at birth, with high hypermetropia and well-corrected with routine spectacles since she was 6 months old.