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Curr Res Transl Med ; 64(2): 91-6, 2016.
Article in English | MEDLINE | ID: mdl-27316392

ABSTRACT

This year (2016) will mark the 10th anniversary of the discovery of induced pluripotent stem cells (iPSCs). The finding that the transient expression of four transcription factors can radically remodel the epigenome, transcriptome and metabolome of differentiated cells and reprogram them into pluripotent stem cells has been a major and groundbreaking technological innovation. In this review, we discuss the major applications of this technology that we have grouped in nine categories: a model to study cell fate control; a model to study pluripotency; a model to study human development; a model to study human tissue and organ physiology; a model to study genetic diseases in a dish; a tool for cell rejuvenation; a source of cells for drug screening; a source of cells for regenerative medicine; a tool for the production of human organs in animals.


Subject(s)
Cellular Reprogramming Techniques , Induced Pluripotent Stem Cells/transplantation , Regenerative Medicine/trends , Animals , Cell Culture Techniques/methods , Cell Lineage , Cell Transdifferentiation/drug effects , Cells, Cultured , Cellular Senescence , Drug Evaluation, Preclinical/methods , Humans , Induced Pluripotent Stem Cells/cytology , Intercellular Signaling Peptides and Proteins/pharmacology , Mice , Organ Culture Techniques/methods , Rejuvenation , Species Specificity , Swine , Therapies, Investigational , Transcription Factors/pharmacology
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