Evaluating pelvic tilt using the pelvic antero-posterior radiographs: A novel method.

Pelvic tilt (PT) is an important parameter for orthopedic surgeries involving hip and spine, typically determined from sagittal pelvic radiographs. However, various challenges can compromise the feasibility of measurement from sagittal imaging, including obscured landmarks, anatomical variations, hardware interference, and limited medical resources. Addressing these challenges and with the aim of reducing radiation exposure to patients, our study developed a novel method to estimate PT from antero-posterior (AP) radiographs, using vertical distances from the pelvic outlet and obturator foramen. We correlated these measurements with PT, defined both anatomically (anterior pelvic plane, PTa) and mechanically (centers of femoral heads and sacral plate, PTm). The study explored creating linear, exponential, and multivariate regression models based on twelve 3D CT-derived pelvic models (six men, six women), simulating AP radiograph projections with controlled PTs. We then validated these models against 105 pairs of patient stereoradiographs. Statistical analysis revealed that combined exponential-linear models yielded the most accurate results, with Pearson correlation coefficients of 0.75 for PTa and 0.77 for PTm, and mean absolute errors of 3.7° ± 2.6° for PTa and 4.5° ± 3.4° for PTm, showing excellent measurement reliability (all ICCs > 0.9) without significant gender discrepancies. In conclusion, this study presents a validated, simple, and accessible method for estimating PT using AP radiograph parameters, supported by the Supporting Information S1: Excel Tool, showing great potential for clinical application in hip and spine procedures.

Advances in imaging for pre-surgical planning in hip resurfacing arthroplasty.

BACKGROUND: Accurate preoperative templating is essential for the success of hip resurfacing arthroplasty (HRA). While digital radiograph is currently considered the gold standard, stereoradiograph and CT converted 3D methods have shown promising results. However, there is no consensus in the literature regarding the preferred modality for HRA templating, and angular measurements are often overlooked. Thus, this study aimed to: (1) compare the performances of different modality in implant sizing and angle measurements, (2) evaluate the measurement reproducibility, (3) assess the impact of severe osteoarthritis on femoral head sizing, and (4) based on the analysis above, explore the optimal imaging and planning strategy for HRA. HYPOTHESIS: An optimal imaging modality exists for HRA planning regarding implant sizing and angular measurements. MATERIALS AND METHODS: Preoperative imaging data from seventy-seven HRA surgeries were collected. Three raters performed templating using digital radiograph, stereoradiograph, and CT converted 3D models. Measurements for femoral head size, neck-shaft angle, and calcar-shaft angle were obtained. The femoral head sizing was compared to the intraoperative clinical decision. The reproducibility of measurements was assessed using the intraclass correlation coefficient (ICC). Correlations were examined between sizing disagreement and osteoarthritis grade (Tonnis Classification). RESULTS: Digital radiograph, stereoradiograph, and 3D techniques predicted one size off target in 27/77 (35%), 49/70 (70%), and 75/77 (97%) of cases, respectively, corresponding to 1.8±1.6 (0 to 5.67), 0.9±0.7 (0 to 2.67), and 0.4±0.4 (0 to 1.67) sizes off target, indicating statistically significant differences among all three modalities, with p-values all below 0.01. There were no statistically significant differences among the different modalities for angular measurements. Measurements showed moderate to excellent reproducibility (ICC=0.628-0.955). High-grade osteoarthritis did not impact image sizing in any modality (r=0.08-0.22, all p>0.05). DISCUSSION: CT converted 3D models were more accurate for implant sizing in HRA, but did not significantly outperform other modalities in angular measurements. Given the high costs and increased radiation exposure associated with CT, the study recommended using CT scans selectively, particularly for precise femoral head sizing, while alternative imaging methods can be effectively used for angular measurements. LEVEL OF EVIDENCE: III; retrospective comparative diagnostic study.

Inadequate Annotation and Its Impact on Pelvic Tilt Measurement in Clinical Practice.

BACKGROUND: Accurate pre-surgical templating of the pelvic tilt (PT) angle is essential for hip and spine surgeries, yet the reliability of PT annotations is often compromised by human error, inherent subjectivity, and variations in radiographic quality. This study aims to identify challenges leading to inadequate annotations at a landmark dimension and evaluating their impact on PT. METHODS: We retrospectively collected 115 consecutive sagittal radiographs for the measurement of PT based on two definitions: the anterior pelvic plane and a line connecting the femoral head's centre to the sacral plate's midpoint. Five annotators engaged in the measurement, followed by a secondary review to assess the adequacy of the annotations across all the annotators. RESULTS: The outcomes indicated that over 60% images had at least one landmark considered inadequate by the majority of the reviewers, with poor image quality, outliers, and unrecognized anomalies being the primary causes. Such inadequacies led to discrepancies in the PT measurements, ranging from -2° to 2°. CONCLUSION: This study highlights that landmarks annotated from clear anatomical references were more reliable than those estimated. It also underscores the prevalence of suboptimal annotations in PT measurements, which extends beyond the scope of traditional statistical analysis and could result in significant deviations in individual cases, potentially impacting clinical outcomes.

Evaluating Pelvic Tilt Using the Pelvic Antero-Posterior Projection Images: A Systematic Review.

BACKGROUND: Pelvic tilt (PT) is a routinely evaluated parameter in hip and spine surgeries, and is usually measured on a sagittal pelvic radiograph. This may not always be feasible due to limitations such as landmark visibility, pelvic anomaly, and hardware presence. Tremendous efforts have been dedicated to using pelvic antero-posterior (AP) radiographs for assessing sagittal PT. Thus, this systematic review aimed to collect these methods and evaluate their performances. METHODS: Two independent reviewers searched the PubMed, Ovid, Cochrane, and Web of Science databases in June 2023 with backward reference trailing (Google Scholar archive). There were 30 studies recruited. Risk of bias was assessed using the prediction model risk of bias assessment tool. The relevant data were tabulated in a standardized form for evaluating either the absolute PT or relative PT. Disagreement was resolved by discussing with the senior author. RESULTS: There were 19 parameters from pelvic AP projection images involved, with 4 studies which used artificial intelligence, eyeball, or statistical shape method not involving a specific parameter. In comparing the PT values from pelvic sagittal images with those extrapolated from antero-posterior projection images, the highest correlation coefficient was found to be 0.91. The mean absolute difference (error) was 2.6°, with a maximum error reaching 10.9°. Most studies supported the feasibility of using AP parameters to calculate changes in PT. CONCLUSIONS: No individual AP parameter was found to precisely estimate absolute PT. However, relative PT can be derived by evaluating serial AP radiographs of a patient in varying postures, employing any AP parameters.

Correlations Analysis of Different Pelvic Tilt Definitions: A Preliminary Study.

Background: Pelvic tilt (PT) is described as the pelvic orientation along the transverse axis, yet 4 PT definitions were established based on radiographic landmarks: anterior pelvic plane (PTa), the center of femoral heads to sacral plate (PTm), pelvic outlet (PTh), and sacral slope (SS). These landmarks quantify a similar concept, yet understanding of their relationships is lacking, and their differences are sometimes ignored. Purpose: This study aimed to examine the correlations and differences of PT definitions for education and research purposes. Methods: This study reviewed 105 sagittal pelvic radiographs of patients (68 men and 37 women) awaiting hip surgery at a single clinic. Hip hardware and spine pathologies were examined for subgroup analysis. Two observers annotated 4 PTs in a gender-dependent manner and repeated it after 6 months. The linear regression model and intraclass correlation coefficient (ICC) were applied with a 95% confidence interval. Results: The SS showed no correlation to the other 3 PT definitions, except for females in the hip hardware subgroup (n = 17). PTm demonstrated very strong linear correlation to PTh (r > 0.9) under the linear model PTm = 0.951 × PTh - 68.284. Conclusion: The PTm and PTh can be calculated from each other under a simple linear regression equation, which enables comparisons between them. SS presented poor correlations to the other PT parameters, except for the female subgroup with hip implant that required further analysis; PTa-related comparisons showed high anatomical variations between patients.

The Sacro-femoral-pubic Angle Is Unreliable to Estimate Pelvic Tilt: A Meta-analysis.

BACKGROUND: The accurate measurement of pelvic tilt is critical in hip and spine surgery. A sagittal pelvic radiograph is most often used to measure pelvic tilt, but this radiograph is not always routinely obtained and does not always allow the measurement of pelvic tilt because of problems with image quality or patient characteristics (such as high BMI or the presence of a spinal deformity). Although a number of recent studies have explored the correlation between pelvic tilt and the sacro-femoral-pubic angle using AP radiographs (SFP method), which aimed to estimate pelvic tilt without a sagittal radiograph, disagreement remains about whether the SFP method is sufficiently valid and reproducible for clinical use. QUESTIONS/PURPOSES: The purpose of this meta-analysis was to evaluate the correlation between SFP and pelvic tilt in the following groups: (1) overall cohort, (2) male and female cohort, and (3) skeletally mature and immature cohorts (young and adult groups, defined as patients older or younger than 20 years). Additionally, we assessed (4) the errors of SFP-estimated pelvic tilt angles and determined (5) measurement reproducibility using the intraclass correlation coefficient. METHODS: This meta-analysis was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and registered in PROSPERO (record ID: CRD42022315673). PubMed, Embase, Cochrane, and Web of Science were screened in July 2022. The following keywords were used: sacral femoral pubic, sacro femoral pubic, or SFP. The exclusion criteria were nonresearch articles such as commentaries or letters and studies that only investigated relative pelvic tilt rather than absolute pelvic tilt. Although the included studies had different patient recruitment strategies, study quality-wise, they all used an adequate amount of radiographs for landmark annotation and applied a correlation analysis for the relationship between the SFP angle and pelvic tilt. Thus, no risk of bias was found. Participant differences were mitigated via subgroup and sensitivity analyses to remove outliers. Publication bias was assessed using the p value of a two-tailed Egger regression test for the asymmetry of funnel plots, as well as the Duval and Tweedie trim and fill method for potential missing publications to impute true correlations. The extracted correlation coefficients r were pooled using the Fisher Z transformation with a significance level of 0.05. Nine studies were included in the meta-analysis, totaling 1247 patients. Four studies were used in the sex-controlled subgroup analysis (312 male and 460 female patients), and all nine studies were included in the age-controlled subgroup analysis (627 adults and 620 young patients). Moreover, a sex-controlled subgroup analysis was conducted in two studies with only young cohorts (190 young male patients and 220 young female patients). RESULTS: The overall pooled correlation coefficient between SFP and pelvic tilt was 0.61, with high interstudy heterogeneity (I 2 = 76%); a correlation coefficient of 0.61 is too low for most clinical applications. The subgroup analysis showed that the female group had a higher correlation coefficient than the male group did (0.72 versus 0.65; p = 0.03), and the adult group had a higher correlation coefficient than the young group (0.70 versus 0.56; p < 0.01). Three studies reported erroneous information about the measured pelvic tilt and calculated pelvic tilt from the SFP angle. The mean absolute error was 4.6° ± 4.5°; in one study, 78% of patients (39 of 50) were within 5° of error, and in another study, the median absolute error was 5.8º, with the highest error at 28.8° (50 female Asian patients). The intrarater intraclass correlation coefficients ranged between 0.87 and 0.97 for the SFP angle and between 0.89 and 0.92 for the pelvic tilt angle, and the interrater intraclass correlation coefficients ranged between 0.84 and 1.00 for the SFP angle and 0.76 and 0.98 for the pelvic tilt angle. However, large confidence intervals were identified, suggesting considerable uncertainty in measurement at the individual radiograph level. CONCLUSION: This meta-analysis of the best-available evidence on this topic found the SFP method to be unreliable to extrapolate sagittal pelvic tilt in any patient group, and it was especially unreliable in the young male group (defined as patients younger than age 20 years). Correlation coefficients generally were too low for clinical use, but we remind readers that even a high correlation coefficient does not alone justify clinical application of a metric such as this, unless further subgroup analyses find low error and low heterogeneity, which was not the case here. Further ethnicity-segregated subgroup analyses with age, sex, and diagnosis controls could be useful in the future to determine whether there are some subgroups in which the SFP method is useful. LEVEL OF EVIDENCE: Level III, diagnostic study.

Predicting Transitioning Walking Gaits: Hip and Knee Joint Trajectories From the Motion of Walking Canes.

In recent years, wearable exoskeletons and powered prosthetics have been considered key elements to remedy mobility loss. One of the main challenges pertaining to this field is the prediction of the wearer's desired motion. In this paper, we perform a human locomotion analysis, and we investigate the accuracy of predicting the angular position of the lower limb joints from the motion of walking canes. Nine healthy subjects took part of this study and performed a locomotor task that comprised straight walking on flat ground, stair ascent, and upright resting posture. Recurrent Neural Networks and polynomial fitting using Least Squares were used to model dynamic and static non-linear mappings, respectively, between the motion of a cane and its contra-lateral leg joints. A successful prediction of both the hip and knee joints was achieved using information from the cane only, and significant improvement of the prediction error was realized through the addition of data from the arm joints. Overall, Recurrent Neural Networks outperformed Least Squares for both joints' angular position prediction. When using the cane only, the static maps were able to predict steady behaviour but failed in predicting transitioning, as opposed to RNN, which was able to capture both steady behaviour and transitions.

Prediction of Smooth Gait Transitioning for Active Lower Limb Prosthetics.

Amputation is the major cause of gait impairment in our society and is due to several factors and conditions such as war injuries or diabetes lower limb complication, often resulting in a gait impairment. Active prosthetics have been considered to remedy this mobility loss. These devices have the potential to enhance significantly the quality of life of patients. One major challenge resides in the generation of smooth trajectories, especially during gait transitioning for the active joints of the powered devices. Here we propose a smooth trajectory predictor for above-knee prosthetics, where the motion of the hip joints is translated into knee and ankle joint trajectories. We consider a locomotion task that includes overground walking and stairs ascent. Successful prediction is achieved for both knee and ankle joint angular positions.

Human locomotion analysis: Identifying a dynamic mapping between upper and lower limb joints using the Koopman operator.

Human locomotion is a complex process that shows some inherent synergies and coordination, also called inter-joint coordination, between the upper and lower limbs. In this paper, we investigate the use of Koopman operator to identify a dynamic mapping between an upper limb and its contra-lateral lower limb in the human locomotion. We perform a human locomotion analysis in the sagittal plane and restrict the study to the forward motion; more specifically, a straight walking task at a constant speed. We use canes as walking aids to provide additional information about the terrain and enforce a frequency locking between the upper and lower body. This mapping will provide a model of the human locomotion.

Design of molecules that specifically recognize and cleave apurinic sites in DNA.

We have prepared a series of tailor-made molecules that recognize and cleave DNA at apurinic sites in vitro. These molecules incorporate in their structure different units designed for specific function: an intercalator for DNA binding, a nucleic base for abasic site recognition and a linking chain of variable length and nature (including amino and/or amido functions). The cleavage efficiency of the molecules can be modulated by varying successively the nature of the intercalating agent, the nucleic base and the chain. All molecules bind to native calf thymus DNA with binding constants ranging from 10(4) to 10(6) M-1. Their cleavage activity was determined on plasmid DNA (pBR 322) containing 1.8 AP-sites per DNA-molecule. The minimum requirements for cleavage are the presence of the three units, the intercalator, the nucleic base and at least one amino function in the chain. The most efficient molecules cleave plasmid DNA at nanomolar concentrations. Enzymatic experiments on the termini generated after cleavage of AP-DNA suggest a strand break induced by a beta-elimination reaction. In order to get insight into the mode of action (efficiency, selectivity, interaction), we have used synthetic oligonucleotides containing either a true abasic site at a determined position to analyse the cleavage parameters of the synthetic molecules by HPLC or a chemically stable analog (tetrahydrofuran) of the abasic site for high field 1H NMR spectrometry and footprinting experiments. All results are consistent with a beta-elimination mechanism in which each constituent of the molecule exerts a specific function as indicated in the scheme: DNA targeting, abasic site recognition, phosphate binding and beta-elimination catalysis.(ABSTRACT TRUNCATED AT 250 WORDS)